Abstract: An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.
Type:
Grant
Filed:
September 7, 2010
Date of Patent:
November 5, 2013
Assignee:
Valeant Pharmaceuticals North America
Inventors:
Haoyun An, Kanda Ramasamy, Stephanie Shaw
Abstract: An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.
Type:
Application
Filed:
September 7, 2010
Publication date:
August 11, 2011
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Haoyun An, Kanda Ramasamy, Stephanie Shaw
Abstract: The invention relates to pharmaceutical combinations of retigabine and sodium channel inhibitors for treating, pains which are accompanied by an increase in muscle tone.
Type:
Application
Filed:
August 30, 2010
Publication date:
December 23, 2010
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Istvan SZELENYI, Kay BRUNE, Robert HERMANN, Mathias LOCHER
Abstract: The invention relates to pharmaceutical combinations of retigabine and sodium channel inhibitors for treating pains which are accompanied by an increase in muscle tone.
Type:
Grant
Filed:
December 5, 2003
Date of Patent:
September 21, 2010
Assignee:
Valeant Pharmaceuticals North America
Inventors:
Istvan Szelenyi, Kay Brune, Robert Hermann, Mathias Locher
Abstract: An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.
Type:
Grant
Filed:
January 15, 2004
Date of Patent:
September 21, 2010
Assignee:
Valeant Pharmaceuticals North America
Inventors:
Haoyun An, Kanda Ramasamy, Stephanie Shaw
Abstract: Novel nucleoside analog compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.
Type:
Grant
Filed:
August 22, 2002
Date of Patent:
December 29, 2009
Assignee:
Valeant Pharmaceuticals North America
Inventors:
Robert Tam, Kandasamy Ramasamy, Zhi Hong, Johnson Lau
Abstract: Novel nucleoside analog compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.
Type:
Application
Filed:
March 9, 2009
Publication date:
July 9, 2009
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Robert Tam, Kanda Ramasamy, Zhi Hong, Johnson Lau
Abstract: The invention relates to pharmaceutical combinations of potassium channel openers and sodium channel inhibitors. for treating pains which are accompanied by an increase in muscle tone.
Type:
Application
Filed:
March 12, 2009
Publication date:
July 9, 2009
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Istvan SZELENYI, Kay BRUNE, Robert HERMANN, Mathias LOCHER
Abstract: This invention provides compounds of formula I where Ar1 is a 5- to 10-member mono- or bicyclic aromatic group, optionally substituted; where the —NR3R4 group is situated ortho to the NHC(?X) group; n=1 or 2; X?O or S; Y is O or S; and q=1 or 0. The invention also provides pharmaceutical compositions comprising compounds of formula I and/or salts, esters, and prodrugs thereof. These compounds modulate the activation and inactivation of potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders—such as seizure disorders—which are affected by modulation of potassium ion channels.
Abstract: This invention provides a compound of formula IA where X?O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.
Type:
Application
Filed:
August 22, 2007
Publication date:
June 12, 2008
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Jean-Michel Vernier, Martha Alicia De La Rosa, Huanming Chen, Jim Zhen Wu, Gary Lee Larson, Ian Wayne Cheney
Abstract: An embodiment of the present invention provides an apparatus for setting a dose of a drug in a syringe having a plunger, comprising an outer housing and an inner housing adapted for encircling the syringe, such that the inner housing is positioned within the outer housing to set the dose of the drug. In an embodiment, the apparatus further comprises a dosage indicator disposed on the inner housing and the outer housing further comprises an opening for viewing the dosage indicator.
Type:
Application
Filed:
January 15, 2008
Publication date:
May 8, 2008
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Michael Horvath, David Jensen, Mark Sponsel, Joseph Rossi, Gregory Malone
Abstract: This invention provides compounds of formula I where X?O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. The invention also provides pharmaceutical compositions comprising compounds of formula I. Such compounds are potassium channel modulators.
Type:
Application
Filed:
August 16, 2007
Publication date:
February 21, 2008
Applicant:
Valeant Pharmaceuticals North America
Inventors:
Jean-Michel Vernier, Samedy Ouk, Martha Alicia De La Rosa, David Abraham Paisner
Abstract: An embodiment of the present invention provides an apparatus for setting a dose of a drug in a syringe having a plunger, comprising an outer housing and an inner housing adapted for encircling the syringe, such that the inner housing is positioned within the outer housing to set the dose of the drug. In an embodiment, the apparatus further comprises a dosage indicator disposed on the inner housing and the outer housing further comprises an opening for viewing the dosage indicator.
Type:
Grant
Filed:
February 14, 2003
Date of Patent:
February 12, 2008
Assignee:
Valeant Pharmaceuticals North America
Inventors:
Michael W. Horvath, David F. Jensen, Mark R. Sponsel, Joseph P. Rossi, Gregory D. Malone
Abstract: Various 2?-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particularly useful as therapeutic agents, and especially as antiviral agents.
Type:
Grant
Filed:
October 23, 2002
Date of Patent:
May 15, 2007
Assignee:
Valeant Pharmaceuticals North America
Inventors:
Haoyun An, Yili Ding, Stephanie Z. Shaw, Zhi Hong