Abstract: A system and methods to perform automated validation and corresponding workflow management are provided. In an illustrative implementation, the present invention comprises a computing application operating in a computing environment that cooperates with at least one data store. The computing application provides a user interface to accept and display data representative of validation processing and/or the corresponding workflow management surrounding the validation lifecycle. In operation, data is accepted through the user interface and processed by the exemplary computing application to generate one or more validation protocols. Further, validation protocols are stored in cooperating data stores for subsequent execution. The exemplary computing application also maintains processing rules that allow participating users to perform workflow management for efforts required to realize the validation lifecycle.