Abstract: A method for surgical trajectory planning, particularly useful for deep brain stimulation. A three-dimensional model of an anatomical structure is rendered, which includes a target site. As the user gazes into the model, eye tracking data is obtained and a line of sight for the target site is identified. A surgical trajectory is determined along the line of sight between the target site and a surgical entry point on the surface of the anatomical structure. The method allows the identification of an optimal surgical trajectory to reach the target site while avoiding key structures within the anatomical structure, such as blood vessels, sulci, ventricles. Advantageously, the model is rendered in a virtual environment, and the eye tracking data is obtained from a VR headset.

Abstract: A method for surgical trajectory planning, particularly useful for deep brain stimulation. A three-dimensional model of an anatomical structure is rendered, which includes a target site. As the user gazes into the model, eye tracking data is obtained and a line of sight for the target site is identified. A surgical trajectory is determined along the line of sight between the target site and a surgical entry point on the surface of the anatomical structure. The method allows the identification of an optimal surgical trajectory to reach the target site while avoiding key structures within the anatomical structure, such as blood vessels, sulci, ventricles. Advantageously, the model is rendered in a virtual environment, and the eye tracking data is obtained from a VR headset.

Abstract: Microfluidic devices, systems and methods are described herein. The devices, systems and methods provide for trapping particles, including cells. Methods of generating a droplet in a microfluidic device and collecting droplets from microfluidic devices are also disclosed herein.

Abstract: Systems, devices and methods for integrating world-to-chip interfaces with digital microfluidics for bacterial transformation and enzymatic assays are described herein. The devices include a microfluidic device having a first plate comprising a cell culture region for maintaining a cell culture and a reservoir for storing reagents to induce at least a portion of the cell culture or to mix with other reagents and a second plate spaced apart from the first plate, the second plate defining one or more openings extending through the second plate. The device may include a reagent well coupled to the second plate. The reagent well may be configured to refill the reservoir on the first plate with liquid reagent via the one or more openings of the second plate. The device may also include a thermoelectric module (TEM) coupled to the first plate or the second plate for managing temperature control of the device.

Abstract: The present disclosure relates to fused N-arylsulfonamidyl-thienoisoquinoline compounds, derivatives and pharmaceutical compositions thereof, and methods and uses in inhibiting cancer cell growth, along with a supplemental anti-cancer agent. Centrosome targeting and microtubule depolymerisation are attractive in designing the present chemotherapeutic compounds. The various diseases and conditions treated include various types of cell cancers, and in vitro inhibition.

Abstract: There are provided various microfluidics devices. Microfluidics devices that include a culture area for mixing a composition and an assay area for measuring enzyme activity of samples of the bacterial culture are, for example, provided. The assay area may include an optical density reader. The optical density reader may include a light emitting source and sensor to allow monitoring of the optical density of samples. Microfluidic devices comprising a first plate comprising at least one hydrophilic site are also provided as well as methods of manufacture thereof. Methods for performing analyses of compositions on microfluidics devices comprising a plate assembly having a first plate and a second plate are also provided in various embodiments.

Abstract: The present invention relates to a method of preparing lanthanide-doped NaYF4 nanocrystals, the method comprising: (A) providing a first solution comprising a non-coordinating solvent, a fatty acid coordinating ligand, sodium trifluoroacetate, yttrium trifluoroacetate, a first doping lanthanide trifluoroacetate and a second doping lanthanide trifluoroacetate, and a second solution comprising the non-coordinating solvent and the fatty acid coordinating ligand, the first and second solutions being substantially free of water and oxygen; (B) in an inert atmosphere, slowly adding the first solution heated at a temperature between about 100° C. and about 150° C. to the second solution heated at temperature between about 290° C. and about 330° C., thereby producing a reaction mixture containing the nanocrystals; and (C) recovering the nanocrystals from the reaction mixture.

Abstract: Provided herein are hybrid catalysts that are used in the deep catalytic cracking of petroleum naphthas or other hydrocarbon feedstocks, for the selective production of light olefins, in particular ethylene and propylene and BTX aromatics. The hybrid catalysts of this invention contain a chemically treated microporous crystalline silicate such as the pentasil-type silicalite, a mesoporous silica-alumina or zirconium oxide co-catalyst, into which may be incorporated aluminum oxide, molybdenum oxide, lanthanum oxide, cerium oxide or a mixture of aluminum and molybdenum oxides, and an inorganic binder such as bentonite clay.