Abstract: A method for surgical trajectory planning, particularly useful for deep brain stimulation. A three-dimensional model of an anatomical structure is rendered, which includes a target site. As the user gazes into the model, eye tracking data is obtained and a line of sight for the target site is identified. A surgical trajectory is determined along the line of sight between the target site and a surgical entry point on the surface of the anatomical structure. The method allows the identification of an optimal surgical trajectory to reach the target site while avoiding key structures within the anatomical structure, such as blood vessels, sulci, ventricles. Advantageously, the model is rendered in a virtual environment, and the eye tracking data is obtained from a VR headset.

Abstract: A filtration membrane is provided. It comprises a porous support substrate and a porous active layer on top of the support substrate, wherein the active layer is formed of a network of interconnected, randomly arranged ceramic splats with ceramic particles occupying interstices between the splats, and wherein free spaces between the particles define a network of interconnected pores extending through the thickness of the active layer. There are also provided a method of filtering a feed using the membrane and a method of manufacturing the membrane by suspension plasma spraying.

Abstract: Microfluidic devices, systems and methods are described herein. The devices, systems and methods provide for trapping particles, including cells. Methods of generating a droplet in a microfluidic device and collecting droplets from microfluidic devices are also disclosed herein.

Abstract: Systems, devices and methods for integrating world-to-chip interfaces with digital microfluidics for bacterial transformation and enzymatic assays are described herein. The devices include a microfluidic device having a first plate comprising a cell culture region for maintaining a cell culture and a reservoir for storing reagents to induce at least a portion of the cell culture or to mix with other reagents and a second plate spaced apart from the first plate, the second plate defining one or more openings extending through the second plate. The device may include a reagent well coupled to the second plate. The reagent well may be configured to refill the reservoir on the first plate with liquid reagent via the one or more openings of the second plate. The device may also include a thermoelectric module (TEM) coupled to the first plate or the second plate for managing temperature control of the device.

Abstract: The present disclosure relates to fused N-arylsulfonamidyl-thienoisoquinoline compounds, derivatives and pharmaceutical compositions thereof, and methods and uses in inhibiting cancer cell growth, along with a supplemental anti-cancer agent. Centrosome targeting and microtubule depolymerisation are attractive in designing the present chemotherapeutic compounds. The various diseases and conditions treated include various types of cell cancers, and in vitro inhibition.

Abstract: Wavelength division multiplexing (WDM) has enabled telecommunication service providers to fully exploit the transmission capacity of optical fibers. State of the art systems in long-haul networks now have aggregated capacities of terabits per second. Moreover, by providing multiple independent multi-gigabit channels, WDM technologies offer service providers with a straight forward way to build networks and expand networks to support multiple clients with different requirements. In order to reduce costs, enhance network flexibility, reduce spares, and provide re-configurability many service providers have migrated away from fixed wavelength transmitters, receivers, and transceivers, to wavelength tunable transmitters, receivers, and transceivers as well as wavelength dependent add-drop multiplexer, space switches etc.

Abstract: Wavelength division multiplexing (WDM) has enabled telecommunication service providers to fully exploit the transmission capacity of optical fibers. State of the art systems in long-haul networks now have aggregated capacities of terabits per second. Moreover, by providing multiple independent multi-gigabit channels, WDM technologies offer service providers with a straight forward way to build networks and expand networks to support multiple clients with different requirements. In order to reduce costs, enhance network flexibility, reduce spares, and provide re-configurability many service providers have migrated away from fixed wavelength transmitters, receivers, and transceivers, to wavelength tunable transmitters, receivers, and transceivers as well as wavelength dependent add-drop multiplexer, space switches etc.

Abstract: There are provided various microfluidics devices. Microfluidics devices that include a culture area for mixing a composition and an assay area for measuring enzyme activity of samples of the bacterial culture are, for example, provided. The assay area may include an optical density reader. The optical density reader may include a light emitting source and sensor to allow monitoring of the optical density of samples. Microfluidic devices comprising a first plate comprising at least one hydrophilic site are also provided as well as methods of manufacture thereof. Methods for performing analyses of compositions on microfluidics devices comprising a plate assembly having a first plate and a second plate are also provided in various embodiments.

Abstract: A heat exchanger including a first plate and a second plate spaced apart from the first plate that defines a first gap between inner surfaces of the first plate and the second plate in which a first fluid circulates, where a major portion of the first gap is free of obstructions, where a second fluid contacts an outer surface of the first or second plate for heat exchange with the first fluid, where a first peripheral wall on the periphery of the first gap has a curved profile inside the first gap, and at least one inlet is radially positioned with respect to the first gap and injects the first fluid in the gap, and least one outlet is centrally positioned in one of the first and the second plate to enable the first fluid to exit the first gap, where first fluid circulates in a swirling flow in the major portion of the first gap.

Abstract: There is described a Minimal Iterativity Anisotropic Diffusion (MIAD) approach that estimates the required number of iterations N as a function of the image structure-under-noise ? and the bound of the noise ?. The time step ? is related to the image structure-under-noise ? and to the bound of noise ?. The stopping time is calculated using T=?·N, and the edge strength ? is determined as a function of T, ?, and ?.

Abstract: A method and system for auctioning an auction item in a multi-attribute auction. A winning bid is selected by determining a secret value function indicative of acceptable combination of attribute values for the auction owner. The auction owner computing device or the auction server generates alternate combinations of attribute values based at least in part on the secret value function. To generate the alternate combinations of attribute values at least some of the combinations of attribute values are perturbed so as to hinder the bidders from deriving or finding the secret value function. The auction server informs the bidders, via a bidder interface of a client computing device, about the alternate combinations of attribute values and required biding directions. The bidder can offer a bid in a next round based on the alternate combinations of attribute values, in a progressive manner and without knowledge of the secret value function.

Abstract: There are provided processes for treating wastewater. The processes can comprise treating a mixture comprising the wastewater and an activated sludge, in a single reactor, with an electric current having a density of less than about 55 A/m2, by means of at least one anode and at least one cathode that define therebetween an electrical zone for treating the mixture; exposing the mixture to an intermittent ON/OFF electrical exposure mode to the electric current in which an OFF period of time is about 1 to about 10 times longer than an ON period of time; and maintaining an adequate oxidation-reduction potential in the single reactor. Such processes allow for substantial removal of carbon, nitrogen and phosphorus from the wastewater in the single reactor of various forms and for obtaining another mixture comprising a treated wastewater and solids.

Abstract: A self-healing material comprises a matrix embedded with micro-pockets of a healing-agent releasable by a crack in the matrix. The healing-agent is able to bond to the matrix to repair the crack. The healing-agent is contained in microcapsules. A corresponding catalyst for the healing-agent is embedded in the matrix and contained in a plurality of microcapsules as an emulsion. The emulsion comprises an oil, a perfluorated solvent, a hydrophobic ionic liquid, or mixtures thereof. A method of manufacturing the self-healing material comprises the steps of identifying an operational temperature range of the material, providing at least one substance as the healing-agent, which substance remaining substantially in a liquid state within the operational temperature range, identifying an operational evaporation rate of the healing-agent and providing the substance with a curing time according to the evaporation rate.

Abstract: A method and system for auctioning an auction item in a multi-attribute auction. A winning bid is selected by determining a secret value function indicative of acceptable combination of attribute values for the auction owner. The auction owner computing device or the auction server generates alternate combinations of attribute values based at least in part on the secret value function. To generate the alternate combinations of attribute values at least some of the combinations of attribute values are perturbed so as to hinder the bidders from deriving or finding the secret value function. The auction server informs the bidders, via a bidder interface of a client computing device, about the alternate combinations of attribute values and required biding directions. The bidder can offer a bid in a next round based on the alternate combinations of attribute values, in a progressive manner and without knowledge of the secret value function.

Abstract: A heat exchanger including a first plate and a second plate spaced apart from the first plate that defines a first gap between inner surfaces of the first plate and the second plate in which a first fluid circulates where a major portion of the first gap is free of obstructions, where a second fluid contacts an outer surface of the first or second plate for heat exchange with the first fluid, where a first peripheral wall on the periphery of the first gap has a curved profile inside the first gap, and at least one inlet is radially positioned with respect to the first gap and injects the first fluid in the gap, and least one outlet is centrally positioned in one of the first and the second plate to enable the first fluid to exit the first gap, where first fluid circulates in a swirling flow in the major portion of the first gap.

Abstract: The invention provides a fast method for a high-quality interpolation of a finite multidimensional dataset. It has particular application in digital image processing, including, but not limited to, processing of both still images and real-time image/data processing. The method uses discrete cosine and sine transforms of appropriate types to covert, in blocks of desired size, the initial dataset to the frequency domain. Proposed interpolators calculate a chain of inverse transforms of non-square sizes that perform the interpolation. The larger transform is broken into smaller transforms of non-square size using a recursive size reduction process of FFT-type, and the smaller transforms are calculated directly exploiting the symmetry properties of smaller interpolator functions involved. An output dataset is then assembled using the calculated transforms. The method avoids computationally costly process of inflating the coefficient space by padding zeros exploited for DCT-based interpolations previously.

Abstract: The present invention relates to a method of preparing lanthanide-doped NaYF4 nanocrystals, the method comprising: (A) providing a first solution comprising a non-coordinating solvent, a fatty acid coordinating ligand, sodium trifluoroacetate, yttrium trifluoroacetate, a first doping lanthanide trifluoroacetate and a second doping lanthanide trifluoroacetate, and a second solution comprising the non-coordinating solvent and the fatty acid coordinating ligand, the first and second solutions being substantially free of water and oxygen; (B) in an inert atmosphere, slowly adding the first solution heated at a temperature between about 100° C. and about 150° C. to the second solution heated at temperature between about 290° C. and about 330° C., thereby producing a reaction mixture containing the nanocrystals; and (C) recovering the nanocrystals from the reaction mixture.

Abstract: A method for determining a hard-landing occurrence for an aircraft has sensors at selected positions of the aircraft. A model defining critical points throughout the aircraft is obtained. Data is received from the sensors when the aircraft lands. Diagnosis values for all critical points of the aircraft are calculated by applying the model to the data from the sensors. The diagnosis values are compared to threshold values for the critical points of the aircraft. A hard-landing occurrence is determined from the comparison between the diagnosis value and the threshold value. A hard-landing occurrence determination system for an aircraft is also provided. Sensors at selected positions of the aircraft provide data related to accelerations at landing of the aircraft. A diagnosis processor unit determines the hard-landing occurrence, and comprises a model database, a threshold database and a threshold comparator. A hard-landing occurrence interface signals a hard-landing occurrence.

Abstract: Diffraction gratings are formed from grooves each having a reflective facet and a non-reflective facet. The net reflection of TE (Transverse Electric) and TM (Transverse Magnetic) polarizations from the grating structure is traded off against the polarization dependent reflection, by controlling the degree of metallization of the reflective facet and by ensuring that there is no metallization of non-reflective sidewalls. other diffraction gratings are manufactured from trenches etched perpendicular to a waveguide. The trenches are metallized and back-filled with a filling material having a refractive index matched to that of the waveguide. The gratings essentially have no non-reflecting sidewalls with insignificant polarization influence from side walls.

Abstract: Provided herein is a method and apparatus for selective deep catalytic cracking of petroleum naphthas or other hydrocarbon feedstocks. The feed comprising the hydrocarbons to be cracked and steam, in well-defined proportions, is first sent into a precatalytic zone (Zone I) of a cracking reactor, preferably a tubular reactor. In a preferred embodiment, Zone I, contains beads of some catalytically mildly active porous material such as quartz or quartz doped with Cr—Al, is set at a temperature T1. The gas steam flows then through a catalyst bed, called Zone II, where the catalytic reaction takes place. Zone II is set at temperature T2 and contains a zeolite type catalyst, preferably ZSM5 zeolite or, most preferably, a hybrid zeolite catalyst.