Abstract: Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases.
Type:
Grant
Filed:
May 5, 2005
Date of Patent:
December 31, 2013
Assignees:
Valorisation-Rechereche Société en Commandite, Valorisation HSJ, Société en Commandite
Inventors:
Sylvain Chemtob, Christiane Quiniou, William D. Lubell, Martin Beauchamp, Karl A. Hansford
Abstract: According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method comprises administration of one or more Growth Hormone Releasing Peptides (GHRPs) to a patient in need of such treatment or prophylaxis. There are also provided methods of reducing blood plasma cholesterol levels, as well as methods of modulating the expression of the scavenger receptor CD36 and genes involved in cellular cholesterol efflux.
Type:
Grant
Filed:
August 21, 2003
Date of Patent:
August 31, 2010
Assignees:
Valorisation-Recherche, Société en Commandite, Valorisation HSJ, Société en Commandite
Inventors:
Huy Ong, Sylvie Marleau, André Tremblay