Abstract: Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases.
Type:
Grant
Filed:
May 5, 2005
Date of Patent:
December 31, 2013
Assignees:
Valorisation-Rechereche Société en Commandite, Valorisation HSJ, Société en Commandite
Inventors:
Sylvain Chemtob, Christiane Quiniou, William D. Lubell, Martin Beauchamp, Karl A. Hansford
Abstract: According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method comprises administration of one or more Growth Hormone Releasing Peptides (GHRPs) to a patient in need of such treatment or prophylaxis. There are also provided methods of reducing blood plasma cholesterol levels, as well as methods of modulating the expression of the scavenger receptor CD36 and genes involved in cellular cholesterol efflux.
Type:
Grant
Filed:
August 21, 2003
Date of Patent:
August 31, 2010
Assignees:
Valorisation-Recherche, Société en Commandite, Valorisation HSJ, Société en Commandite
Inventors:
Huy Ong, Sylvie Marleau, André Tremblay
Abstract: The present invention relates to IL-23 receptor antagonists and agonists. The use of IL-23 receptor antagonists in treating autoimmune and inflammatory disorders, as well as methods of identifying IL-23 receptor antagonists and agonists.
Type:
Application
Filed:
July 7, 2008
Publication date:
July 29, 2010
Applicant:
Valorisation HSJ, Societe en Commandite
Inventors:
Sylvain Chemtob, Christiane Quiniou, William D. Lubell
Abstract: The invention provides polypeptides, nucleic acids, antibodies, compositions, vaccines, microarrays and uses thereof for the prevention, treatment of HCV infection. The invention further provides uses of the above-noted products for the detection and diagnosis of HCV infection. The invention further provides corresponding methods and commercial packages relating to such uses. The invention further provides recombinant polypeptides and methods for their production.
Type:
Application
Filed:
November 18, 2005
Publication date:
September 24, 2009
Applicant:
Valorisation HSJ, Societe en Commandite
Inventors:
Hugo Soudeyns, Myriam Troesch, Emilie Jalbert
Abstract: The present invention relates to cytokine receptor-binding compounds, such as non-competitive VEGF receptor, IL-1 receptor, IL-4 receptor, or IGF-1 receptor-binding peptides and petidomimetic antagonists, and therapeutic uses of such compounds. The compounds of the present invention may be used in the treatment of cytokine-associated diseases such as proliferative disorders (for example, colon, breast, prostate, and lung cancer), abnormal neovascularization and angiogenesis, age-related macular degeneration, and proliferative and/or inflammatory skin disorders such as psoriasis.
Type:
Application
Filed:
May 5, 2006
Publication date:
February 19, 2009
Applicant:
Valorisation HSJ, Societe en Commandite
Inventors:
Sylvain Chemtob, Christiane Quiniou, Martin Beauchamp