Abstract: Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases.
Type:
Grant
Filed:
May 5, 2005
Date of Patent:
December 31, 2013
Assignees:
Valorisation-Rechereche Société en Commandite, Valorisation HSJ, Société en Commandite
Inventors:
Sylvain Chemtob, Christiane Quiniou, William D. Lubell, Martin Beauchamp, Karl A. Hansford
Abstract: There are provided compounds of formulas (VA), (VIA), (VIIA) (IXA), (XIA), (XIIA), (XIIIA), and (XIVA): wherein A, Z, R2, X?, and L2 represent various different possibilities.
Type:
Application
Filed:
October 5, 2006
Publication date:
August 23, 2007
Applicant:
VALORISATION-RECHERECHE
Inventors:
Andre Charette, Jean-Christophe Poupon, Alessandro Boezio