Patents Assigned to Van Andel Institute; and the USA as Represented by the Department Of Veterans Affairs
  • Publication number: 20050118165
    Abstract: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase. Met and its agonist ligand HGF. Disclosed herein are (a) mAbs and hybridoma cell lines that produce them, which mAbs antibodies are specific for Met and (b) combinations of anti-Met and anti-HGF mAbs. When detectably labeled, these antibodies are useful for imaging such tumors. Anti-Met mAb compositions and methods for scintigraphic detection, diagnosis, prognosis, monitoring and therapy of Met-bearing tumors are provided.
    Type: Application
    Filed: December 27, 2002
    Publication date: June 2, 2005
    Applicant: Van Andel Institute; and the USA as Represented by the Department Of Veterans Affairs
    Inventors: Rick Hay, Boliang Cao, James Resau, George Vande Woude, Milton Gross