Abstract: An antibody-based GnRH receptor antagonist and methods of making and using same are disclosed. The antibody-based GnRH receptor antagonist is a GHR-106 monoclonal antibody (GHR-106) or an antigen-binding fragment thereof. GHR-106 or its IgG fragments can be utilized for therapeutic applications in the treatment of cancer and a range of sex hormone-related disorders or conditions in male or female subjects for which decapeptide GnRH antagonists are currently used.

Abstract: A system is disclosed for holding a panel in a u-channel comprising a rocking grip configured to be positioned in the u-channel on a first side of the panel and a tilting grip configured to be positioned in the u-channel on a second side of the panel, opposite the first side for adjusting an angular position of the panel. The rocking grip includes a rotatable rocking plate for abutting the first side of the panel. The tilting grip includes a tilting plate for abutting the second side of the panel a moveable top cam for rotating the tilting plate in a first direction and a moveable bottom cam for rotating the tilting plate in a second direction, opposite the first direction.

Abstract: Provided herein are methods of diagnosing and/or treating ACVS, by determining expression levels of several ACVS-related molecules, such as FABP3, ANPR-1, IGFBP-3, F9, SELL, apoB100, ADPN, vWF, THBS1, PRL, PON3, EGFR, VEGF-D, HPX, MBT, F5, F10, SERPIN A5, HCII, and HABP2, for example in a blood sample.

Abstract: Provided herein are humanized forms of murine RP215 monoclonal antibodies and methods of using the same. These humanized RP215 monoclonal antibodies were characterized in terms of their respective affinity and specificity to the corresponding tumor-associated antigen, CA215, and shown to be comparable to those of murine RP215.

Abstract: A cutting tool comprising a body, an aperture defined through the body, a blade coupled to the body, and at least one protrusion extending from the body into the aperture. The blade has a cutting edge extending into the aperture. The protrusion(s) has(have) an end portion proximate the cutting edge and configured to impede access to the cutting edge. The protrusion(s) may be flexible, such that limited access to the cutting edge is permitted in a flexed state.

Abstract: Immunogenic compositions that contain haptens consisting of carbohydrate moieties are useful to induce an immune response to provide antibodies to epitopes contained in CA215 and also to elicit an immune response to cancers expressing these epitopes.

Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.

Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.

Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.

Abstract: The effective epitope of CA215, a known cancer marker and antigen, has been demonstrated to include a carbohydrate moiety of defined composition and to be non-reactive with anti-human IgG, IgA and IgM, although CA215 is an immunoglobulin heavy chain-like molecule. The defined epitope may be used to prepare immunogenic compositions for treatment and prevention of cancers in humans and may be optimized as to protocol and formulation in animal model systems. Improved protocols for diagnosis and treatment are also described.

Abstract: A system and method of measuring volatile and semi-volatile reduced organic compound content and volatile and semi-volatile oxidized organic compound content in a sample, using a dual detection system is provided. The method comprises introducing the sample into a semi-permeable membrane introduction interface, sweeping permeate from the membrane introduction interface with a sweep gas, splitting the permeate into a first stream and a second stream, essentially simultaneously detecting volatile and semi-volatile reduced organic compounds and oxidized and semi-volatile organic compounds with a flame ionization detector and an electron capture detector, and computing differences in detector signals, thereby measuring volatile and semi-volatile reduced organic content and volatile and semi-volatile oxidized organic compound content in the sample.

Abstract: A kiosk for processing arriving travelers is provided, wherein the kiosk reads information from the traveler's travel document, and either receives a completed declaration form from the traveler or poses a series of questions to the traveler. On obtaining the needed information from the traveler, the kiosk queries a government computer to obtain a code for the traveler. The code, when shown to a government official, such as a customs agent, will determine if the traveler is retained for secondary processing.

Abstract: A membrane introduction mass spectrometry (MIMS) sampling interface is presented that demonstrates improved online performance for the direct, real-time measurement of semi-volatile organic compounds (SVOCs) in samples such as air and water, at parts-per-billion and parts-per-trillion levels. The device is based upon a capillary hollow fiber silicone (polydimethylsiloxane) membrane in a ‘flow-over’ configuration that is resistively heated on the membrane interior. One embodiment resistively heats using a coaxial nichrome wire, establishing a thermal gradient counter to the analyte concentration gradient. This arrangement allows for continuous and/or pulsed heating modes, affording excellent sensitivity for the online measurement of SVOCs while retaining sensitivity for volatile organic compounds (VOCs). In addition, the signal response time for SVOCs is reduced substantially over conventional MIMS methods.

Abstract: The present invention relates to a way of planning an action, namely deciding whether the action is generic or unique and then planning the action according to a first procedure if the action is generic or alternatively planning the action according to a second procedure if the action is unique. The first procedure includes budgeting resources in accordance with geo-historical data and index adjustment. The second procedure includes dividing the action into a list of tasks and then for each task: determining a set of resource requirements for completing the task; specifying each resource requirement; for each specified resource requirement, identifying at least one satisfactory available resource; and respectively matching one identified resource to each specified resource requirement. The second procedure is particularly well adapted for balancing other factors in addition to financial cost and for allocating accountability very precisely.

Abstract: A tool for applying grout into a recess between adjacent tile surfaces comprises a body for gripping by the user formed with an elongate, resilient channel member adapted for retaining a line of grout and delivering the grout directly into the recess by aligning and pressing of the channel member over the recess. A finishing portion can be formed on the same body or a separate body for compressing and shaping the grout after delivery into the recess. The tool of the present invention avoids wasting of grout and increases the speed of application without sacrificing the appearance or integrity of the grout joint.

Abstract: A coin collecting cart for collecting coins from parking meters. A plurality of bins are used, each bin being limited to a certain quantity of coins which quantity of coins is electronically sensed. When the first of the bins is full of coins, the coins pass to the second of the bins and so on. When the bins are full, they are individually removable from the cart and mountable within a frame located remotely from the cart. The bins are unloaded by manually rotating the frame together with the bin about an axis.

Abstract: A cutting and grinding tool for removing grout from between tiles comprises a rotatable cutting disc formed with a plurality of radially extending teeth about the circumference of the disc. A drive gear engagable with the teeth is rotated by a power drill to exert a drive force to rotate the cutting disc. The disc teeth serve a dual function of performing a cutting and grinding operation and transmitting the drive force of the drive gear to rotate to the disc. The tool is simple in construction, reliable in operation and easy to control in order to efficiently remove grout from between tiles.

Abstract: A hand held tool for the uniform compressing, forming and simultaneous cleaning of a previously applied bead of caulking or other similar fluent material from a constructed joint. The tool includes an elongated handle and triangular head with working edges, the working edges being essentially an arrow-like shaped pieced or rubber-like material fixed to and extending slightly beyond the acute isosceles triangular shaped head portion of the tool at the extremity opposite an elongated handle, the acute angle of the working edges at the extremity is slightly rounded. The head and the handle contain a continuous longitudinal cavity provided for the collection of excess material gathered during the operation of the tool and in the preferred embodiment the head and handle are essentially molded as one unit in resilient plastic material with the handle expanding in a fan-like shape the outer angles of the head.

Abstract: A saw arbor formed of a mandrel and a cylindrically apertured sleeve. Circumferentially spaced splines are provided around the mandrel's outer circumference and around the inner circumference of the sleeve aperture. The mandrel splines and the sleeve aperture splines are shaped and sized for slidable mating engagement of the mandrel splines with the aperture splines. Circumferentially spaced splines are also provided around the sleeve's outer circumference. The sleeve outer circumference splines are shaped and sized for slidable mating engagement with further splines spaced circumferentially around a saw blade eye. Equal numbers of equally spaced involute splines are preferably provided around the mandrel, around the inner circumference of the sleeve aperture and around the sleeve's outer circumference. The splines can be formed to achieve backlash tolerance engagement in the range of 0.001" to 0.