Patents Assigned to Vanderbilt University
  • REAL-TIME POSE AND MAGNETIC FORCE DETECTION FOR WIRELESS MAGNETIC CAPSULE
    Publication number: 20150342501
    Abstract: Systems and methods are described for determining an orientation and position of a capsule inserted into the body of a patient. A magnetic field is applied to an area of the patient where the capsule is located. Sensor data, including inertial data from an inertial sensor and magnetic field data indicative of the applied magnetic field as detected by at least one magnetic field sensor, is wirelessly received from the capsule. An orientation angle of the capsule is determined based at least in part on the inertial data. The magnetic field data is compared to known characteristics of the applied magnetic field and a location of the capsule is determined based on the comparison.
    Type: Application
    Filed: January 17, 2014
    Publication date: December 3, 2015
    Applicant: Vanderbilt University
    Inventors: Christian Di Natali, Marco Beccani, Pietro Valdastri, Keith L. Obstein
  • SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
    Publication number: 20150336925
    Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
    Type: Application
    Filed: September 20, 2013
    Publication date: November 26, 2015
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Taekyu Lee, Nicholas F. Pelz, Johannes Belmar, Zhiguo Bian, Edward T. Olejniczak, Stephen W. Fesik, Brian A. Chauder
  • Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 9192603
    Abstract: Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: November 24, 2015
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins, Colleen M. Niswender, Rocco D. Gogliotti, James M. Salovich, Darren W. Engers, Yiu-Yin Cheung
  • ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20150322163
    Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.
    Type: Application
    Filed: July 27, 2015
    Publication date: November 12, 2015
    Applicants: VANDERBILT UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Andras Gruber, Erik I. Tucker, Stephen Raymond Hanson, David Gailani
  • CHANGE MANAGEMENT SYSTEM, CHANGE MANAGEMENT METHOD, AND CHANGE MANAGEMENT PROGRAM
    Publication number: 20150324305
    Abstract: A change management system includes a system definition expansion unit 11 which generates information of a state machine set made up of one or more state machines, from a system definition. The system definition includes one or more primitives and any number of wirings. Each of the primitives includes any number of wire ports. Each of the wire ports includes one state machine. Each of the wirings connects to two wire ports included in different primitives. The system definition expansion unit 11 generates the information of the state machine set, by connecting existing definitions of the primitives by the wirings.
    Type: Application
    Filed: August 28, 2014
    Publication date: November 12, 2015
    Applicants: VANDERBILT UNIVERSITY, NEC CORPORATION
    Inventors: Takayuki KURODA, Aniruddha Suresh GOKHALE
  • FAST CHANGE PLANNING SYSTEM, FAST CHANGE PLANNING METHOD, AND FAST CHANGE PLANNING PROGRAM
    Publication number: 20150323916
    Abstract: A fast change planning system includes: a state machine set division unit 11 which divides a state machine set made up of one or more state machines, into a state machine group set; and a state machine set integration unit 12 which integrates transition orders derived from each of the state machine groups obtained by dividing the state machine group set.
    Type: Application
    Filed: August 28, 2014
    Publication date: November 12, 2015
    Applicants: VANDERBILT UNIVERSITY, NEC CORPORATION
    Inventors: Takayuki KURODA, Aniruddha Suresh GOKHALE
  • CHANGE PLANNING SYSTEM, CHANGE PLANNING METHOD, AND CHANGE PLANNING PROGRAM
    Publication number: 20150324211
    Abstract: A change planning system includes a state machine set conversion unit 11 which converts a state machine set made up of one or more state machines, into a single state machine including one or more states, wherein a state in a state machine included in the state machine set transitions to another state according to a transition condition designating a state in a state machine included in the state machine set other than the state machine, wherein a state in the single state machine corresponds to a state of all state machines in the state machine set, and wherein, while the transition condition according to which the state in the state machine makes a predetermined transition is satisfied, the state in the single state machine transitions to another state corresponding to another state of all state machines that results from the predetermined transition.
    Type: Application
    Filed: August 28, 2014
    Publication date: November 12, 2015
    Applicants: VANDERBILT UNIVERSITY, NEC CORPORATION
    Inventors: Takayuki KURODA, Aniruddha Suresh GOKHALE
  • Powered leg prosthesis and control methodologies for obtaining near normal gait
    Patent number: 9180025
    Abstract: A powered leg prosthesis including a powered knee joint with a knee joint and a knee motor unit for delivering power to the knee joint, a powered ankle joint coupled to the knee joint including an ankle joint and an ankle motor unit to deliver power to the ankle joint, a prosthetic foot coupled to the ankle joint, a plurality of sensors for measuring a real-time input, and controller for controlling movement of the prosthesis based on the real-time input. In the powered leg prosthesis, at least one of the knee motor unit or the ankle motor unit includes at least one drive stage, where the drive stage includes a rotary element for generating torque and at least one looped element affixed around the rotary element and configured for transmitting the torque to another rotary element coupled to a joint to be actuated.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: November 10, 2015
    Assignee: Vanderbilt University
    Inventors: Michael Goldfarb, Huseyin Atakan Varol, Frank Charles Sup, IV, Jason Mitchell, Thomas J. Withrow
  • mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 9180192
    Abstract: Pyrazole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: November 10, 2015
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins, Colleen M. Niswender, Rocco D. Gogliotti
  • Methods of using an antibody to inhibit WNT-mediated signaling in cancer
    Patent number: 9175090
    Abstract: The present invention is directed to monoclonal antibodies and fragments thereof directed to LRP5/6 that find use in the prevention and treatment of cardiac remodeling and cancer. Also disclosed are methods for using such monoclonal antibodies in the prevention and treatment of such diseases.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 3, 2015
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Ethan Lee, Pampee P. Young, Josiane Eid, Robert Carnahan, Curtis Thorne, Kelly Meyers
  • Control system for a grasping device
    Patent number: 9174339
    Abstract: A method for operating a grasping device and grasping devices therefrom are provided. The grasping device is configured to use a plurality of parallel, bi-directional state flow maps each defining a sequence of poses for a plurality of joints in the grasping device. The method include receiving at least one control signal, determining a current pose of the grasping device within the one of the plurality of state flow maps currently selected for the grasping device, and selectively actuating the plurality of joints to traverse the sequence of poses, where a direction for traversing the sequence of poses is based on the at least one control signal.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: November 3, 2015
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Michael Goldfarb, Skyler Dalley, Huseyin Atakan Varol
  • NORMALLY CLOSED MICROVALVE AND APPLICATIONS OF THE SAME
    Publication number: 20150308578
    Abstract: A normally closed valve includes a plurality of fluid channels in fluid communication with each other, defined in a flexible base such that when a fluid channel is compressed, a fluid flow through the fluid channel is occluded, otherwise, the fluid flow through the fluid channel is unoccluded; and means for selectively compressing or uncompressing a desired fluid channel.
    Type: Application
    Filed: November 21, 2013
    Publication date: October 29, 2015
    Applicant: Vanderbilt University
    Inventors: Frank E. Block, III, Philip C. Samson, John P. Wikswo
  • Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
    Patent number: 9161983
    Abstract: Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: October 20, 2015
    Assignee: Vanderbilt University
    Inventors: Eva M Harth, Dain B. Beezer, GuangZhao Li, Benjamin R. Spears, David M. Stevens
  • Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 9163015
    Abstract: Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: October 20, 2015
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins, Colleen M. Niswender, Rocco D. Gogliotti, James M. Salovich, Darren W. Engers, Yiu-Yin Cheung
  • Tumor suppressor killin
    Patent number: 9140705
    Abstract: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: September 22, 2015
    Assignee: Vanderbilt University
    Inventors: Peng Liang, Yong-Jig Cho
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9133212
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 15, 2015
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Compositions and methods for the treatment of disorders involving epithelial cell apoptosis
    Patent number: 9133249
    Abstract: The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn's disease or ulcerative colitis) in a subject, such as a human patient.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: September 15, 2015
    Assignee: VANDERBILT UNIVERSITY
    Inventors: D. Brent Polk, Fang Yan
  • Isoform selective phospholipase D inhibitors
    Patent number: 9127005
    Abstract: Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: September 8, 2015
    Assignee: Vanderbilt University
    Inventors: H. Alex Brown, Craig W. Lindsley, Alex G. Waterson, Sarah A. Scott
  • Anti-factor XI monoclonal antibodies and methods of use thereof
    Patent number: 9125895
    Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: September 8, 2015
    Assignees: Oregon Health & Science University, Vanderbilt University
    Inventors: Andras Gruber, Erik I. Tucker, Stephen Raymond Hanson, David Gailani
  • POLY(THIOKETAL-URETHANE) SCAFFOLDS AND METHODS OF USE
    Publication number: 20150231302
    Abstract: The presently-disclosed subject matter includes biodegradable scaffolds. Exemplary biodegradable scaffolds comprise a plurality of polythioketal polymers, and a plurality of polyisocyanates, where at least one polyisocyanate is linked to at least one polymer to form the scaffold. Thus, certain embodiments of scaffolds comprise a cross-linked network of the polythioketal polymers and the polyisocyanates. The presently-disclosed subject matter also includes methods for treating tissue, such as skin or bone tissue, in a subject in need thereof. Treatment methods comprise contacting the tissue with an effective amount of the biodegradable scaffold. Furthermore, the presently-disclosed subject matter includes methods for making the present biodegradable scaffolds.
    Type: Application
    Filed: September 20, 2013
    Publication date: August 20, 2015
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Craig L. Duvall, Scott A. Guelcher, Mukesh Kumar Gupta, John Martin, Jonathan Page