Abstract: A powered leg prosthesis includes powered knee joint comprising a knee joint and a knee motor unit for delivering power to the knee joint. The prosthesis also includes a prosthetic lower leg having a socket interface coupled to the knee joint and a powered ankle joint coupled to the lower leg opposite the knee joint comprising an ankle joint and an ankle motor unit to deliver power to the ankle joint. The prosthesis further includes a prosthetic foot coupled to the ankle joint, at least one sensor for measuring a real-time input, and at least one controller for controlling movement of the prosthesis based on the real-time input.

Abstract: Heat-transfer fluids and lubricating fluids comprising deaggregated diamond nanoparticles are described herein. Also described are composites comprising deaggregated diamond nanoparticles, and methods of making such composites. Method of using deaggregated diamond nanoparticles, for example, to improve the properties of materials such as thermal conductivity and lubricity are also disclosed.

Abstract: In one aspect, the invention relates to substituted pyrazolo[1,5-a]pyrazine compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Copolymers, such as block copolymers, having at least one block that is a random copolymer of ?-caprolactone and a-carboxy-s-caprolactone are disclosed. Also described are methods of using such copolymers, such as, for example, in medical devices.

Abstract: The present invention includes a cleavable surfactant/detergent compound of the following formula: wherein the variables are defined herein. Embodiments of the cleavable surfactant/detergent compound are useful, for example, in methods for isolating a hydrophobic molecule that include providing a plasma comprising a hydrophobic molecule, applying the cleavable surfactant to the plasma so that the surfactant engages the hydrophobic molecule, cleaving the surfactant from the hydrophobic molecule, and analyzing said hydrophobic molecule.

Abstract: In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Polar nematic compounds, one example of which has the following structure: is a caged boron structure, where the sphere of the caged boron structure is C and each non-sphere vertex of the caged boron structure is B—H. R is H, an alkyl, a cycloalkyl, a bicycloalkyl, an alkenyl, a cycloalkenyl, a bicycloalkenyl, an alkynyl, an acyl, an aryl, an alkylaryl, a halogen, a cyano group, or an isothiocyanoto group, or R is a group that forms an ether, a ketone, an ester, a thioester, a sulfide, or a sulfone. X is COOR? or COSR?. R? is H, an alkyl, a cycloalkyl, a bicycloalkyl, an alkenyl, a cycloalkenyl, a bicycloalkenyl, an alkynyl, an aryl, a halogen, or a cyano group. The compounds may be used in liquid crystal displays (LCDs), and in television sets, laptop computers, computer monitors, hand-held communication devices, gaming devices, watches, cash registers, clocks, and calculators having liquid crystal displays.

Abstract: In one aspect, the invention relates to compounds having a general structure: which are useful as selective allosteric or bitopic agonists of the M1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.

Abstract: A system and method of wireless controlled CO2 insufflation for use in colon capsule endoscopy. The system includes a device to inflate the colon through the use of a swallowable capsule including a first compound and a second compound for generating a biocompatible chemical reaction that provides a level of insufflation to enhance visualization and to allow for magnetic locomotion within the colon. The chemical reaction achieves relevant colon insufflation (enough to enable diagnostic relevance) by producing CO2 (carbon dioxide).

Abstract: The present invention provides methods for treating or limiting development of inflammatory disorders.

Abstract: A system and method of detecting and assessing a tissue surface property without a separate access port to internal anatomical structures. The system includes a first unit positioned outside the patient's body and a second unit positioned inside the patient's body. The first unit includes a magnetic field source and a force sensor and is positioned outside the patient's body in a position that enables magnetic coupling with the second unit, which is inside the patient's body. The second unit includes a magnetic field source, a processor, a sensor, a telemetry unit, a power source, and an optional actuator or other components. The resulting attractive force between the internal and external magnetic field sources can be perceived by the force sensor of the first unit. By varying the distance between the two units, the attractive force triggers a variable stress on the tissue surrounding the second unit in the direction of the magnetic field source in the first unit.

Abstract: An immunoisolation patch system, and particularly a patch system comprising multiple immunoisolation microcapsules, each encapsulating biological material such as cells for transplantation, which can be used in the prophylactic and therapeutic treatment of disease in large animals and humans without the need for immunosuppression.

Abstract: In one aspect of the present invention, a method of transient and selective suppression of neural activities of a target of interest, such as one or more nerves, includes selectively applying at least one light to the target of interest at selected locations with predetermined radiant exposures to create a localized and selective inhibitory response therein. The localized and selective inhibitory response comprises a local temperature change.

Abstract: One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter.

Abstract: A method of making an electrode useable in an electrochemical cell, includes the steps of (a) providing an electrically conductive substrate; (b) forming nanostructured current collectors on the conductive substrate; and (c) attaching nanoparticles of a ternary orthosilicate composite to the nanostructured current collectors. The ternary orthosilicate composite includes Li2MnxFeyCozSiO4, where x+y+z=1.

Abstract: This invention provides methods and systems for detecting interaction between members of a binding pair. The method involves associating one member of the binding pair with a nanoparticle and detecting the interaction between the two molecules by back-scattering interferometry.

Abstract: In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A drug delivery device includes a catheter having first and second ends; a flexible membrane having a rim securely connected to an inner surface of the catheter to define a first volume between the first end and the flexible membrane, and a second volume between the flexible membrane and the second end, such that the second volume is substantially the same as a desired drug volume; and a pressurizable member coupled to the catheter for operably delivering a drug. In use, a desired volume of the drug is preloaded into the second volume of the catheter that in turn is slid into a guidance device, when the guidance device is placed in a target of interest, the pressurizable member applies a pressure into the first volume to exert a force upon the flexible membrane to operably squeeze the second volume, thereby unloading the drug into the target.