Abstract: The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients with multiple sclerosis, and that anti-chlamydial agents improve or sustain neurological function in these patients.
Type:
Grant
Filed:
February 17, 2005
Date of Patent:
August 22, 2006
Assignee:
Vanderbilt Unversity
Inventors:
Charles W. Stratton, William M. Mitchell, Subramaniam Sriram
Abstract: This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F.sub.2 -like compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.