Abstract: A method and apparatus for screening luggage are provided. X-ray images derived by scanning the luggage with X-rays are received and processed with an automated threat detection (ATD) engine. A determination is then made whether to subject respective ones of the X-ray images to further visual inspection by a human operator at least in part based on results obtained by the ATD engine. In certain cases, visual inspection by a human operator is by-passed and the ATD results are relied upon in order to mark luggage for further inspection or to mark luggage as clear. In another aspect, X-ray images derived by scanning the luggage using two or more X-ray scanning devices are pooled at a centralized location. ATD operations are applied to the X-ray images, which are then provided “on-demand” to a human operator for visual inspection. Results of the visual inspection are entered by the human operator and then conveyed to on-site screening technicians associated with respective X-ray scanning devices.