Abstract: Provided herein are devices, systems, and methods for providing respiratory therapy to a patient using a nasal cannula comprising a cannula body, first and second inlet tubes, and a nasal prong for the delivery of a flow of breathing gas to the patient. Configured with the cannula is a nebulizer having an aerosol generator positioned to emit aerosolized medicament along a longitudinal axis of the nasal prong. A flow director is configured to direct the flow of breathing gas into the nasal prong such that the breathing gas flows along the longitudinal axis, such that the flow of aerosolized medicament is contained within the flow of breathing gas as it moves along the longitudinal axis of the nasal prong for delivery to the patient.

Abstract: An adaptive gas mixture controller system. A pulse oximeter interface receives pulse oximeter data. A gas blender interface communicates with a separate externally connected gas blender. A processor receives pulse oximeter data via the pulse oximeter interface and outputs data to the gas blender interface for adaptive feedback control of the gas mixture based upon the SpO2 level signals from the pulse oximeter interface. When the processor receives data from the gas blender indicating that the gas mixture has been manually changed, enters a manual override mode and halts sending adaptive feedback control signals to the gas blender. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: A computer implemented method is disclosed for providing adaptive control of a gas mixture for delivery to a patient via a separate external gas blender system. The computer implemented method includes receiving first SpO2 data from a regional oximeter via a regional oximeter interface; determining first PaO2 data using a first lookup table derived from a first sigmoid shaped oxyhemoglobin dissociation curve; determining a first gas mixture value using the first PaO2 data; and transmitting first adaptive feedback control data including the first gas mixture value to the separate external gas blender system via a gas blender interface.

Abstract: Devices and methods for providing respiratory therapy are disclosed. One device includes a first lumen, a second lumen, and a bridge with at least one opening. The first lumen has a first inlet end to receive a first flow of breathing gas, a first outlet end to deliver the first flow, and a first bend between the first inlet end and the first outlet end. The second lumen has a second inlet end to receive a second flow of breathing gas, a second outlet end to deliver the second flow, and a second bend between the second inlet end and the second outlet end. The bridge separates the first lumen and the second lumen, attaches to the first lumen at the first bend and the second lumen at the second bend, and is configured to maintain the first flow of breathing gas separate from the second flow of breathing gas.

Abstract: Apparatus and methods for delivering humidified breathing gas to a patient are provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit. The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received by the base unit.

Abstract: Systems and methods for providing respiratory therapy are disclosed. The system includes a nebulizer operable to aerosolize a medicament, a cylindrical mixing chamber, an impacting cap and a recirculation tube. The mixing chamber has an inlet port, an outlet port, an aerosol port in fluid communication with the nebulizer, and a drainage port. The inlet port receives a flow of breathing gas. The mixing chamber receives the aerosol via the aerosol port, entrains aerosol into the flow of breathing gas, and delivers the breathing gas entrained with aerosol to the outlet port. The impacting cap receives and coalesces a portion of the aerosol into droplets within the space defined by the mixing chamber and the impacting cap. The mixing chamber is also configured to direct rain-out resulting from the droplets to the drainage port. The system also includes a recirculation tube to return the rain-out to the nebulizer.

Abstract: Systems, devices, and methods for coupling a tracheostomy tube to a source of humidified breathing gas are disclosed. An adaptor includes a housing, a tracheostomy tube connection device, and a baffle. The housing has an interior surface, an exterior surface, and a breathing gas port. The tracheostomy tube connection device is positioned within the housing and includes an input port for receiving a flow of humidified breathing gas from the breathing gas port and an output port for coupling with the tracheostomy tube. The tracheostomy tube connection device has an internal surface defining a breathing gas passage and an external surface spaced from the interior surface of the housing to create a condensation passage. The baffle may be positioned between the breathing gas port and the input port to cause controlled condensation from the flow of humidified breathing gas by disrupting the flow of humidified breathing gas.

Abstract: A cannula for providing respiratory therapy to a patient includes a first nasal prong having a proximal end attached to a cannula body and a distal end for insertion into a nare of the patient. The first nasal prong defines a lumen for a flow of breathing gas from a source of breathing gas to the nare of the patient, and the first nasal prong has a variable geometry such that a cross-sectional area of the lumen at the distal end of the first nasal prong varies with a flow rate of the breathing gas. Varying the cross-sectional area of the first nasal prong lumen with the flow rate of the breathing gas enables the first nasal prong to maintain a high velocity flow to the nare for effective flushing of the patient's airway.

Abstract: Systems, methods, and devices for humidifying a breathing gas are presented. The system includes a source of pressurized breathing gas, a vapor transfer unit external to the source of pressurized breathing gas, a first gas tube connecting the source of pressurized breathing gas to the gas inlet of the vapor transfer unit and having a first length, a liquid supply having a heater that heats liquid, a first liquid tube coupling the liquid supply to the liquid inlet of the vapor transfer unit, and a second gas tube having a second length and connecting the gas outlet to a patient interface. The first length is greater than the second length. The vapor transfer unit includes a gas passage, a liquid passage, and a membrane separating the gas passage and the liquid passage. The membrane is positioned to transfer vapor from the liquid passage to the gas passage.

Abstract: A system for respiratory therapy may include a nebulizer, an adaptor, and a nasal cannula. The nebulizer is operable to generate an aerosolized medicament and pass the aerosolized medicament through a nebulizer outlet port. The adaptor has a nebulizer coupling port configured to be coupled to the nebulizer outlet port. The nasal cannula is configured to provide a flow of breathing gas from a breathing gas source to the patient. The nasal cannula includes at least one nasal prong and an attachment device positioned adjacent the at least one nasal prong. The attachment device is configured to secure the adaptor outlet port adjacent an outlet of the nasal prong. A method includes securing a nasal cannula to the patient, attaching an adaptor to the nasal cannula, generating an aerosolized medicament, transferring the aerosolized medicament into the adaptor, and providing a flow of breathing gas to the patient.

Abstract: Devices for providing respiratory therapy to a patient are disclosed. One device includes first and second elongated lumens and a nosepiece. The elongated lumens each have a constant internal diameter. The nosepiece portion has a third lumen and a fourth lumen. The third and fourth lumens have constant internal diameters equal to those of the first and second lumens. The third and fourth lumens have inlet ends adapted to be connected to the outlet ends of the first and second lumens without constricting the internal diameter of the first and second lumens. The third and fourth lumens are configured to receive first and second flows of breathing gas from the first and second lumens and deliver the flows of breathing gas to outlets end of the third and fourth lumens. The second flow of breathing gas is maintained separate from the first flow of breathing gas within the nosepiece portion.

Abstract: Systems, devices, and methods are disclosed for nasal cannulas allowing simultaneous flow of humidified breathing gas and aerosolized medicament for use in respiratory therapy. Utilizing separate flow paths and separate cannula outlets for the heated and humidified breathing gas and for the aerosolized medicament, these systems, methods, and devices reduce condensation of the aerosolized medicament by delaying mixing of the flow of aerosolized medicament and the flow of heated and humidified breathing gas until the flows exit the cannula.

Abstract: Systems, methods, and devices for humidifying a breathing gas are presented. The system includes a base unit, a vapor transfer unit, a nasal cannula, and a liquid container. The base unit includes a blower. The vapor transfer unit is external to the base unit and includes a gas passage, a liquid passage, a gas outlet, and a membrane separating the gas passage and the liquid passage. The membrane permits transfer of vapor into the gas passage from liquid in the liquid passage. The nasal cannula is coupled to the gas outlet. The liquid container is configured to reversibly mate with the base unit.

Abstract: A nasal cannula is described herein for respiratory therapy which includes a first gas supply tub with a distal end terminating in a first connector, and a nasal cannula body which includes a first end rotatably coupled to the first connector, a second end opposite the first end, a longitudinal axis extending from the first end to the second end, and a first nasal prong in fluid communication with the first gas supply tube. The first nasal prong is rotatable relative to the first gas supply tube about the longitudinal axis of the nasal cannula body.

Abstract: Systems, methods, and devices are disclosed for manufacturing a vapor transfer cartridge with a constant inner diameter to maximize the area available for fibers required for heating and humidifying a breathing gas. In one aspect, a vapor transfer cartridge includes a center tube extending along a first axis from a first to a second end, having a continuous inner diameter, a first header piece configured as a cap and including a channel about an inner circumference of the header piece coupled to the first end of the center tube, a second header piece coupled to the second end of the center tube, and a plurality of fibers arranged along the axis of the center tube from the first end to the second end. The first header piece further includes a first port, and a baffle.

Abstract: A humidification canister for humidifying a breathing gas, the humidification canister includes a fluid supply configured to supply a fluid and a first gas flow path in fluid communication with the fluid supply. A first gas flow path is configured to humidify the breathing gas with the fluid. A second gas flow path at least partially surrounds the first gas flow path. A method of insulating a breathing gas in a humidification canister using a gas is also disclosed.

Abstract: An adaptive gas mixture controller system. A pulse oximeter interface receives pulse oximeter data. A gas blender interface communicates with a separate externally connected gas blender. A processor receives pulse oximeter data via the pulse oximeter interface and outputs data to the gas blender interface for adaptive feedback control of the gas mixture based upon the SpO2 level signals from the pulse oximeter interface. When the processor receives data from the gas blender indicating that the gas mixture has been manually changed, enters a manual override mode and halts sending adaptive feedback control signals to the gas blender. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: Apparatus and methods for delivering a heated and humidified mixture of oxygen and air are provided. The apparatus includes an air compressor and oxygen concentrator enclosed in the housing of a vapor transfer system. The air compressor supplies air at a first pressure to a gas inlet. The oxygen concentrator provides oxygen at a second pressure to the gas inlet. The oxygen concentrator and the air compressor are in fluid communication and are configured such that the first pressure of the compressed air and the second pressure of the oxygen are about equal. The apparatus includes a vapor transfer system having a gas passage, a liquid passage having heated liquid and vapor, and a membrane that separates the gas passage and liquid passage. The membrane is positioned to transfer vapor from the liquid passage to the gas passage.

Abstract: Methods, systems, and apparatuses are described that indicate an amount at which various gas flow rates should be manually adjusted in order to achieve targeted total flow rates and concentration levels.

Abstract: Apparatus and methods for delivering humidified breathing gas to a patient are provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit. The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received by the base unit.