Abstract: Vacuum pumping apparatus includes a rotor, a motor for rotating the rotor about an axis of rotation, a stator mounted in proximity to the rotor and a housing enclosing the rotor and the stator. The stator includes at least one spiral channel having an open side facing the rotor. The housing defines an inlet in fluid communication with the inner portion of the spiral channel. Gas is pumped outwardly with respect to the axis of rotation through the spiral channel as the motor rotates the rotor. The stator may include two or more spiral channels coupled in parallel. The spiral channels may decrease in cross-sectional area from larger at the inner portion of the stator to smaller at the outer portion of the stator. The vacuum pumping apparatus may include a second vacuum pumping stage on a second side of the rotor and a series connection between the first and second vacuum pumping stages. The second vacuum pumping stage may have a variety of different configurations.

Abstract: Flow cells and stationary-sample vessels (test tubes) are used sequentially in the same dual-function nuclear magnetic resonance (NMR) probe. The user can easily convert the probe between flow and stationary-sample configurations without removing the probe housing. Tapered guiding surfaces are provided for guiding stationary-sample vessels from above and flow cells from below to respective measurement positions. Sample flow connection tubing used during flow measurements is accommodated within the probe during stationary-sample measurements. The dual-function NMR probe is useful in continuous flow-through, stop-flow, and fixed-sample analysis applications, including applications that couple high-pressure liquid chromatography (HPLC) with nuclear magnetic resonance spectroscopy and applications for analyzing small quantities of stationary organic samples.

Abstract: An ion pump anode eliminates the intercellular spaces while maintaining an efficient cell shape in which the plasma sheath follows the contour of the cell wall. The cell are preferably quasi-cylindrical and can be manufactured by folding one or more metal strip into a corrugation and welding the strip to create separate cells. By eliminating the intercellular region, which support a high plasma density, the formation of dendrites under such a region is prevented and instabilities caused by those dendrites are eliminated.

Abstract: An NMR probe, lacking electrical balance in respect of the RF coil thereof, includes a conducting shield of axial extent greater than &lgr;/4 from the ground plane closure of said shield of the probe (&lgr; being the highest resonant frequency of interest), the components of the probe other than the coil being confined to the axial region less than &lgr;/4 from the ground plane and spaced apart from the shield.

Abstract: A bypass valve allows fast and reliable sequential transfer of samples from a 96-well plate to a flow-through nuclear magnetic resonance (NMR) probe of an NMR spectrometer. The bypass valve has three ports: an inject port connected to a first input of the flow-through probe; a load port connected to a needle capable of drawing the samples from the 96-well plate; and a hold port connected to a holding loop. The syringe pump draws a sample from the 96-well plate through the needle and the bypass valve into the holding loop. The position of the bypass valve is switched, and the sample and a dose of push solvent are pushed into the flow-through probe through the bypass valve. After NMR measurements are performed on the sample, the sample is drawn into the holding loop through the bypass valve, at the same time as air is flushed through the probe. The position of the bypass valve is again switched, and the sample is pushed out through the needle.

Abstract: Superconducting birdcage coil with low-pass and high-pass coil configurations are formed by using strips each with an elongated sapphire substrate with a layer of a high temperature superconductor (HTS) material grown in a wavy pattern over its entire length on one of its main surfaces. A low-pass coil is formed with a pair of ring elements made of an electrically conductive metal and a plurality of such strips arranged parallel to one another and interconnecting these ring elements at junctions which are spaced peripherally along each of the rings. At each of the junctions, the ring element and the HTS layer form a capacitance. A highpass coil is formed by a plurality of such strips each with electrodes of the HTS material also grown at two end positions separated from each other on the other main surface of its sapphire substrates. These strips are arranged parallel to each other and sequentially around a central axis, each lying in a plane which includes the center axis.

Abstract: A birdcage-like coil with a pair of electrically conductive ring elements separated in a longitudinal direction and interconnected by three longitudinally extending electrically conductive elongated strips, two of which are diametrically oppositely disposed and the third is azimuthally at 90E from both of them, can create an RF magnetic field gradient when driven in a certain resonance mode. A similarly structured birdcage-like coil with a fourth strip to have two diametrically oppositely disposed strips can create two switchable orthogonal magnetic field gradient by switching off a selected one of the strips and driving the coil in a certain mode. A coil for generating alternative a homogeneous field and selectably one of two orthogonal gradient fields is formed by sandwiching a prior art birdcage long-pass coil with a pair of such coils and by switching on and off suitable ones of the switches in the strips.

Abstract: A radiotherapy machine beam treats a region of a subject while the region and volumes abutting the region are imaged by a magnetic resonance imaging system. The beam and an excitation coil assembly of the imaging system are arranged so the beam is not incident on the coil assembly and magnetic fields derived from the coil assembly do not interact with the beam. The excitation coil assembly includes two spaced winding segments for producing a main DC magnetic field; the segments are located on opposite sides of the region. In one embodiment, wherein the excitation coil assembly is mounted independently of movement of an axis of the beam, the winding segments have a common axis generally aligned with an axis about which the beam axis turns. A treatment couch for the subject fits within aligned central openings of the winding segments. The coil produces main magnetic field lines that extend generally in the same direction as the axis about which the beam turns.

Abstract: A re-entrant radio-frequency (RF) TE11-mode cavity resonator allows generating a spatially homogeneous RF magnetic field for magnetic resonance (NMR, MRI) applications. The azimuthal current distribution is truly (continuously) sinusoidal. Moreover, the geometry allows tuning the cavity resonance frequency over a wide range. The resonator includes an outer cylindrical shell, and an inner re-entrant shell extending only along the ends of the outer shell. The magnetic resonance target of interest is placed in the middle region of the outer cylindrical shell. Multiple re-entrant inner shells can be used, particularly if multiple resonances are desirable. The resonator can be driven capacitively or inductively, for example by placing excitation loops in the space between the outer and inner shell. Multiple excitation loops are used to drive the resonator in quadrature. The resonance frequency of the cavity can be tuned by rotating tuning paddles placed between the inner and outer shells.

Abstract: Observation of transient phenomena in an oversampled regime is implemented with a digital filter pre-charged with a list of pseudodata obtained by prepending one or more pseudo datums to the oversampled data to constitute an effective data set wherein each pseudodatum is derived from the complex conjugate of a corresponding actual datum symmetrically disposed with respect to the time origin.

Abstract: A magnetic field generated by windings supported by a cylindrical former having axis Z is established in a desired direction forming an angle &PHgr; with respect to Z. Over an interval on Z, substantially constant value for the desired field and substantially vanishing orthogonal components are achieved by specifying the current distribution on the cylinder as a solution to field equations and then approximating said current distribution in a discrete conductor forming a plurality of anharmonic loops, nonlinearly spaced in accord with said solution.

Abstract: An apparatus for tuning and/or matching a RF coil in a NMR probe comprising a first variable capacitor electrically connected to the coil and a first motor capable of coupling to the first variable capacitor. The first motor when coupled to the first capacitor adjusts a capacitance associated with the first capacitor. The first motor is capable of operating in a strong magnetic field and is capable of not disturbing homogeneity of said magnetic field when said motor is not operating. The apparatus may further include a second variable capacitor and a second motor. The first motor is further capable of coupling to the second capacitor for adjusting a capacitance associated with the second capacitor. The second motor moves the first motor between coupling with the first capacitor and coupling with the second capacitor. The mechanism may be employed to manipulate variable inductive loads for tuning and/or matching.

Abstract: A z-axis magnetic field gradient coil for nuclear magnetic resonance (NMR) spectrometry includes an etched double-sided flexible sheet having via connections running through the sheet. The vias interconnect two conductive patterns formed on opposite sides of the sheet. Each z-axis current lead is adjacent to another z-axis current lead oriented in the opposite direction, such that the z-axis current components of the two patterns cancel each other. The resulting net current component is in the x-y plane, and generates the desired z-axis magnetic field gradient.

Abstract: A gas chromatographic device has an inlet system, a column and a pressure reducing means combined and assembled in such a series arrangement that provides adequate system performance with shorter wide bore column length and shorter sample analysis times needed during a peak integration and evaluation process performed by a connected mass spectrometer system. Pressure reducing means may be integral part of the inlet system or the column when positioned between the inlet system and the column. Pressure reducing means preferably positioned before the column and being capable of reducing the pressure prevailing at the inlet of said pressure reducing means to a column outlet pressure which is essentially vacuum. Preferably, the inlet pressure of the device is in a range between 10 kPa and 1000 kPa and the absolute pressure prevailing at the outlet of said pressure reducing means is in a range between 0.00001 kPa and 50 kPa.

Abstract: A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.

Abstract: An ion source for use with an ion trap mass spectrometer. The ion source includes an electron source which produces a stream of electrons. The electrons are injected into an ionization chamber by the action of a repeller plate and electron lens. Inside the ionization chamber, the electrons interact with a gas-phase sample to produce sample ions through the electron ionization process, or with a reagent gas to form reagent ions as part of a chemical ionization process. The sample ions produced are extracted from the ionization chamber by the action of an ion repeller and an ion lens. The potentials on the electron repeller and lens, and ion repeller and lens are controlled to direct the electron stream away from the ionization chamber or to direct the sample ion beam away from an ion trap at the appropriate times during measurement of the sample ions.

Abstract: A birdcage coil comprises a number of elements in birdcage geometry wherein the density of elements is such that the contribution to the total inductance from the mutual inductance of said legs exceeds 45% by conventional model calculation. To accommodate the desired density of elements, necessary capacitances are obtained from compact structures such as inter-digitated patterns which may be oriented axially or between elements, or from arrangements of element portions on opposite sides of a cylindrical substrate.

Abstract: An apparatus for electrospray ionization of a liquid sample matrix to prepare the sample for introduction into a mass spectrometer. The inventive electrospray interface is arranged between a source of a liquid sample matrix and an electrospray ionization needle. The interface includes a central chamber which contains elements for passively mixing the liquid sample flow with a modifying liquid added to the central chamber through a side channel. The side channel is isolated from the central chamber by a flow restrictor and the modifying liquid is provided to the side channel through a valve. A second valve, side channel, and flow restrictor are used to permit introduction of a calibration fluid into the central chamber through the first side channel. The inventive interface permits mixing of a modifying liquid with the liquid sample matrix to assist in nebulization of the liquid sample by reducing the surface tension of the sample containing fluid.

Abstract: A sputter ion pump incorporating a corrugated style anode comprising a plurality of cylindrical adjacent hollow cells provided with cross sections having substantially the same area and an arcuated perimeter.

Abstract: A coil set and its design is described for obtaining a magnetic field gradient oriented at a desired angle to a uniform magnetic field wherein the coils set is disposed on a cylinder with axis along the desired gradient direction.