Patents Assigned to Variety Children's Hospital d/b/a Miami Children's Hospital
  • Compositions and Uses of Amooranin Compounds
    Publication number: 20090203634
    Abstract: Amooranin (AMR) has been found to cause tumor cell death through G2/M cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds, including AMR analogs, can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.
    Type: Application
    Filed: April 14, 2006
    Publication date: August 13, 2009
    Applicant: Variety Children's Hospital d/b/a Miami Children's Hospital
    Inventors: Cheppail Ramachandran, P.K. Raveendran Nair, Steven J. Melnick