Abstract: The invention provides methods of reducing or decreasing a size of a tumor or eliminating a tumor by inhibiting, decreasing, or reducing neo-vascularization or angiogenesis in a tumor in a patient by administering an adenovirus comprising a nucleic acid construct comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter. Also provided is a homogeneous population of an adenovirus comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter and its uses thereof.
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
April 26, 2022
Assignee:
Vascular Biogenetics Ltd.
Inventors:
Eyal Breitbart, Andrea Leubitz, Erez Feige, Richard Penson