Patents Assigned to Vasopharm GmbH
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20230355630
    Abstract: Disclosed is a method of preparing a solution adapted for administration by infusion, comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4·2H2O and Na2HPO4·2H2O, and wherein the quantity of the NaH2PO4·2H2O and Na2HPO4·2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4·H2O and Na2HPO4·2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5 and optionally NaCl. Also disclosed is a method of treating a disease in a subject, comprising the step of administering to a subject in need thereof a reconstituted solution as disclosed.
    Type: Application
    Filed: July 20, 2023
    Publication date: November 9, 2023
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 11717522
    Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): ?and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4·2H2O and Na2HPO4·2H2O, and wherein the quantity of the NaH2PO4·2H2O and Na2HPO4·2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4·2H2O and Na2HPO4·2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: August 8, 2023
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20220031703
    Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2H2O and Na2HPO4.2H2O, and wherein the quantity of the NaH2PO4.2H2O and Na2HPO4.2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2H2O and Na2HPO4.2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.
    Type: Application
    Filed: January 20, 2021
    Publication date: February 3, 2022
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20210137927
    Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2H2O and Na2HPO4.2H2O, and wherein the quantity of the NaH2PO4.2H2O and Na2HPO4.2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2H2O and Na2HPO4.2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.
    Type: Application
    Filed: January 20, 2021
    Publication date: May 13, 2021
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 10925877
    Abstract: Compositions comprising derivatives of biopterin, useful for the treatment of traumatic brain injury, non-traumatic brain injury, elevated cranial pressure, and secondary brain injury.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: February 23, 2021
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20200046710
    Abstract: The present invention relates to a method of a method of treating a disease in a subject.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 13, 2020
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 10493075
    Abstract: The present invention relates to a method of preparing 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride dihydrate.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: December 3, 2019
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20180289714
    Abstract: The present invention relates to a method of preparing 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride dihydrate.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of suchcompositions
    Patent number: 10016431
    Abstract: The present invention relates to a method of treating a disease in a subject, comprising administering to a subject in need thereof a solid pharmaceutical composition biopterin derivatives.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: July 10, 2018
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 9895372
    Abstract: The present invention relates to solid pharmaceutical compositions comprising biopterin derivatives as well as methods for obtaining such solid pharmaceutical compositions. The invention also relates to the solid pharmaceutical compositions of the invention for treating diseases.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 20, 2018
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species
    Patent number: 9422289
    Abstract: The present invention relates to the use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: August 23, 2016
    Assignee: VASOPHARM GMBH
    Inventors: Robert Doblhofer, Frank Tegtmeier
  • Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species
    Patent number: 9382252
    Abstract: The present invention relates to the use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: July 5, 2016
    Assignee: VASOPHARM GMBH
    Inventors: Robert Doblhofer, Frank Tegtmeier
  • USE OF PTERIDINE DERIVATIVES FOR THE TREATMENT OF INCREASED INTRACRANIAL PRESSURE, SECONDARY ISCHEMIA, AND DISORDERS ASSOCIATED WITH AN INCREASED LEVEL OF CYTOTOXIC REACTIVE OXYGEN SPECIES
    Publication number: 20130131071
    Abstract: The present invention relates to the use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species.
    Type: Application
    Filed: January 10, 2013
    Publication date: May 23, 2013
    Applicant: VASOPHARM GMBH
    Inventor: VASOPHARM GMBH
  • Substituted 1,2,3-triazolopyrimidines for the inhibition of NAD(P)H oxidases and platelet activation
    Patent number: 8236809
    Abstract: The invention relates to compounds of formula het-X-AB containing a N-heteroaryl moiety “het”, which is linked via X=sulfur to the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl moiety AB of the formula (II). The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidase-related diseases and disorders and inhibition of platelet activation.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: August 7, 2012
    Assignee: Vasopharm GmbH
    Inventors: Frank Tegtmeier, Ulrich Walter, Reinhard Schinzel, Kirstin Wingler, Peter Scheurer, Harald Schmidt
  • 4-amino-7,8-dihydropteridines, pharmaceutical compositions containing them and their use for the treatment of diseases which are caused by an increased nitric oxide level
    Patent number: 7541360
    Abstract: The present invention relates to the area of NO synthase inhibition and, more particularly, relates to novel 4-amino-7,8-dihydropteridines, pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment of a disorder characterized by a disturbed nitric oxide level.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 2, 2009
    Assignee: Vasopharm GmbH
    Inventors: Robert Doblhofer, Frank Tegtmeier