Patents Assigned to Vastogen, Inc.
  • METHODS FOR CONSTRUCTING COPIES OF NUCLEIC ACID MOLECULES
    Publication number: 20240360498
    Abstract: Methods for constructing consecutively connected copies of nucleic acid molecules are disclosed. Consecutively connected copies of nucleic acid molecules can be used to perform sequencing of the same nucleic acid molecules several times, improving overall accuracy of sequencing. Connected copies of nucleic acid molecules can be constructed by circularizing nucleic acid molecules, performing rolling circle amplification and debranching with nicking and polymerases comprising 5?-3? exonuclease and/or flap endonuclease activity.
    Type: Application
    Filed: April 9, 2024
    Publication date: October 31, 2024
    Applicant: Vastogen, Inc.
    Inventor: Dimitra Tsavachidou
  • Methods for constructing copies of nucleic acid molecules
    Patent number: 11981961
    Abstract: Methods for constructing consecutively connected copies of nucleic acid molecules are disclosed. Consecutively connected copies of nucleic acid molecules can be used to perform sequencing of the same nucleic acid molecules several times, improving overall accuracy of sequencing. Connected copies of nucleic acid molecules can be constructed by circularizing nucleic acid molecules, performing rolling circle amplification and debranching with nicking and polymerases comprising 5?-3? exonuclease and/or flap endonuclease activity.
    Type: Grant
    Filed: January 21, 2018
    Date of Patent: May 14, 2024
    Assignee: Vastogen, Inc.
    Inventor: Dimitra Tsavachidou