Abstract: The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
Type:
Application
Filed:
December 16, 2022
Publication date:
February 13, 2025
Applicants:
Imperial College Innovations Limited, VaxEquity Ltd
Abstract: The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
Type:
Application
Filed:
December 17, 2021
Publication date:
April 18, 2024
Applicants:
Imperial College Innovations Limited, VaxEquity Ltd
Inventors:
Robin Shattock, Paul McKay, Michael Watson, Elaine Harper
Abstract: The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
Type:
Application
Filed:
December 17, 2021
Publication date:
November 16, 2023
Applicants:
Imperial College Innovations Limited, VaxEquity Ltd
Inventors:
Robin Shattock, Paul McKay, Michael Watson, Elaine Harper