Abstract: A method for medical skills training is provided that includes simulating a current condition of at least one simulated patient wherein the current condition comprises dynamic physiology, appearance, and behavior of the patient using one or more physiology models; outputting the simulated patient in the current condition on a visual display; receiving input from one or more users, wherein the input represents one or more medical interactions to be virtually applied to the simulated patient; processing the inputs using the physiology model in conjunction with one or more physiological variables that change over time based on the physiology model, in response to corresponding deterioration clocks and the inputs; and outputting one or more changes to the current condition of the simulated patient by applying different animations to the simulated patient based on the processed inputs. As system and computer readable media for medical skills training are also provided.