Patents Assigned to Vect-Horus
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Patent number: 11712486Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.Type: GrantFiled: January 30, 2018Date of Patent: August 1, 2023Assignees: VECT-HORUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLEInventors: Cédric Malicet, Pascaline Lecorche, Jonathan Nowak, Marion David, Jamal Temsamani, Michel Khrestchatisky
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Patent number: 9821072Abstract: The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions of the invention may be used, e.g., to reduce body temperature, attenuate or halt seizures, reduce excitotoxicity, promote neuroprotection, reduce neuroinflammation and aberrant axonal sprouting or reduce pain.Type: GrantFiled: January 19, 2015Date of Patent: November 21, 2017Assignees: VECT-HORUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Guillaume Jacquot, Pascaline Lecorche, Michel Khrestchatisky
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Patent number: 9328143Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorize molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).Type: GrantFiled: May 14, 2014Date of Patent: May 3, 2016Assignees: VECT-HORUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LA MEDITERRANEE (AIX MARSEILLE II)Inventors: Michel Khrestchatisky, Marion David, Yves Molino, Patrick Vlieghe
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Patent number: 8877716Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and the use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides of the invention can be used, in particular, to vectorize, generally in the form of prodrug conjugates, molecules of pharmaceutical or diagnostic interest such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes of different tissues or organs, healthy or pathologic, and in particular to enable their transport across physiological barriers of the nervous system such as the Blood brain barrier (BBB), Blood-spinal cord barrier (BSCB), or Blood-retinal barrier (BRB).Type: GrantFiled: October 19, 2012Date of Patent: November 4, 2014Assignees: Vect-Horus, Centre National de la Recherche Scientifique, Universite D'Aix-MarseilleInventors: Patrick Vlieghe, Marion David, Yves Molino, Michel Khrestchatisky
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Publication number: 20140243499Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).Type: ApplicationFiled: May 14, 2014Publication date: August 28, 2014Applicants: Vect-Horus, Centre National De La Recherche Scientifique, Universite D'Aix MarseilleInventors: MICHEL KHRESTCHATISKY, MARION DAVID, YVES MOLINO, PATRICK VLIEGHE
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Patent number: 8729029Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).Type: GrantFiled: October 20, 2009Date of Patent: May 20, 2014Assignees: Vect-Horus, Centre National de la Recherche Scientifique, Universite d'Aix-MarseilleInventors: Michel Khrestchatisky, Marion David, Yves Molino, Patrick Vlieghe
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Publication number: 20130108548Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and the use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides of the invention can be used, in particular, to vectorize, generally in the form of prodrug conjugates, molecules of pharmaceutical or diagnostic interest such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes of different tissues or organs, healthy or pathologic, and in particular to enable their transport across physiological barriers of the nervous system such as the Blood brain barrier (BBB), Blood-spinal cord barrier (BSCB), or Blood-retinal barrier (BRB).Type: ApplicationFiled: October 19, 2012Publication date: May 2, 2013Applicants: VECT-HORUS, UNIVERSITE DE LA MEDITERRANEE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: VECT-HORUS, Center National De La Recherche Scientifique, UNIVERSITE DE LA MEDITERRANEE
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Publication number: 20110230416Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).Type: ApplicationFiled: October 20, 2009Publication date: September 22, 2011Applicants: Vect-Horus, Centre National De La Recherche Scientifique, Universite De La MediterraneeInventors: Michel Khrestchatisky, Marion David, Yves Molion, Patrick Vlieghe