Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and the use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides of the invention can be used, in particular, to vectorize, generally in the form of prodrug conjugates, molecules of pharmaceutical or diagnostic interest such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes of different tissues or organs, healthy or pathologic, and in particular to enable their transport across physiological barriers of the nervous system such as the Blood brain barrier (BBB), Blood-spinal cord barrier (BSCB), or Blood-retinal barrier (BRB).
Type:
Grant
Filed:
October 19, 2012
Date of Patent:
November 4, 2014
Assignees:
Vect-Horus, Centre National de la Recherche Scientifique, Universite D'Aix-Marseille
Inventors:
Patrick Vlieghe, Marion David, Yves Molino, Michel Khrestchatisky
Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).
Type:
Application
Filed:
May 14, 2014
Publication date:
August 28, 2014
Applicants:
Vect-Horus, Centre National De La Recherche Scientifique, Universite D'Aix Marseille
Inventors:
MICHEL KHRESTCHATISKY, MARION DAVID, YVES MOLINO, PATRICK VLIEGHE
Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).
Type:
Grant
Filed:
October 20, 2009
Date of Patent:
May 20, 2014
Assignees:
Vect-Horus, Centre National de la Recherche Scientifique, Universite d'Aix-Marseille
Inventors:
Michel Khrestchatisky, Marion David, Yves Molino, Patrick Vlieghe
Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).
Type:
Application
Filed:
October 20, 2009
Publication date:
September 22, 2011
Applicants:
Vect-Horus, Centre National De La Recherche Scientifique, Universite De La Mediterranee
Inventors:
Michel Khrestchatisky, Marion David, Yves Molion, Patrick Vlieghe