Abstract: The pharmaceutical compositions including a slightly soluble drug incorporated in a water-swellable, but water-insoluble cross-linked polymer, a surface active agent, and an oil show much improved dissolution and, consequently, bioavailability in respect of the drug as is or used with a polymeric carrier of said type.

Abstract: Pharmaceutical compositions in the form of particles comprising a biodegradable polymer and/or a polysaccharide jellifying and/or bioadhesive polymer, an amphiphilic polymer, an agent modifying the interface properties of the particles and a pharmacologically active substance. Said compositions exhibit improved biocompatibility features and allow a controlled release of the active substance.

Abstract: There are described transdermal therapeutic compositions showing an improved shelf stability of the chemical-physical structure of the medicament and particularly useful for its cutaneous administration, said compositions consisting of a supporting rigid sheet, a polymetic matrix and a protective removable sheet, wherein said polymeric matrix consists of a polymeric film in which there are distributed particles loaded with medicaments and agents promoting the cutaneous absorption.

Abstract: A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a solvent able to swell the polymer. The product obtained by this treatment, and after being dried under vacuum, has a medicament dissolving rate which is considerably higher than that of the pure medicament.

Abstract: Pharmaceutical compositions in the form of particles comprising a biodegradable polymer and/or a polysaccharide jellifying and/or bioadhesive polymer, an amphiphilic polymer, an agent modifying the interface properties of the particles and a pharmacologically active substance. Said compositions exhibit improved biocompatibility features and allow a controlled release of the active substance.

Abstract: Supported drugs with an increased dissolution rate, prepared by a process comprising mixing the drug with the support material under dry conditions, co-grinding the mixture in a mill with its grinding chamber saturated with the vapour of one or more solvents able to solubilize the drug or to be adsorbed on the surface of the support material, vacuum-drying the product obtained, and sieving. The drugs obtained in this manner have a reduced heat of fusion, a reduced melting point, an increased dissolution rate and an increased solubilization kinetics.

Abstract: A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a solvent able to swell the polymer. The product obtained by this treatment, and after being dried under vacuum, has a medicament dissolving rate which is considerably higher than that of the pure medicament.

Abstract: Pharmaceutical tablets and capsule granulates for oral administration, with controlled release of the active substance, comprising scleroglucan and active substance and pharmaceutical acceptable excipients, said tablets being prepared by mechanically mixing said substances in the solid state and directly compressing, and said granulates being prepared by mechanically disintegrating said tablets.

Abstract: Pharmaceutical tablets and capsule granulates for oral administration, with controlled release of the active substance, comprising scleroglucan and active substance and pharmaceutical acceptable excipients, said tablets being prepared by mechanically mixing said substances in the solid state and directly compressing, and said granulates being prepared by mechanically disgregating said tablets.

Abstract: Pharmaceutical compositions including a microporous support and an active substance incorporated therein, the incorporation of the active substance being effected by adding the microporous support to a solution of the active substance, stirring the mixture obtained for at least 70 hours at ambient temperature and finally evaporating the solvent slowly.