Patents Assigned to Vegenics Pty Ltd
  • Combination Treatment with VEGF-C Antagonists
    Publication number: 20130344065
    Abstract: The invention relates to a method and kit for treating cancer in a human subject, the method comprising administering to the subject in combination therapeutically effective amounts of a VEGF-C antagonist and an anti-neoplastic composition, and the kit comprising a VEGF-C antagonist for administering to the subject in combination with an anti-neoplastic composition. The invention further relates to methods for: increasing the duration of survival of, increasing the progression-free survival of, increasing the duration of response of, or treating, a subject or a group of human subjects susceptible to or diagnosed as having a cancer; or treating a human subject or a group of human subjects having metastatic colorectal cancer, prostate cancer, pancreatic cancer or glioblastoma, the methods comprising administering to the subject or subjects in the group in combination effective amounts of a VEGF-C antagonist and an anti-neoplastic composition.
    Type: Application
    Filed: August 29, 2013
    Publication date: December 26, 2013
    Applicant: Vegenics Pty Ltd
    Inventor: Megan E. Baldwin
  • Use of VEGF-D gene to prevent restenosis
    Patent number: 8455453
    Abstract: The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth Factor D (VEGF-D) genes or proteins.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: June 4, 2013
    Assignee: Vegenics Pty Ltd
    Inventors: Kari Alitalo, Seppo Ylä-Herttuala, Mikko O. Hiltunen, Markku M. Jeltsch, Marc G. Achen
  • SCREENING AND THERAPY FOR LYMPHATIC DISORDERS INVOLVING THE FLT4 RECEPTOR TYROSINE KINASE (VEGFR-3)
    Publication number: 20120010276
    Abstract: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 12, 2012
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, VEGENICS PTY LTD
    Inventors: ROBERT E. FERRELL, Kari Alitalo, David N. Finegold, Marika Karkkainen
  • Modified VEGF-A with improved angiogenic properties
    Patent number: 8025886
    Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: September 27, 2011
    Assignee: Vegenics Pty Ltd
    Inventors: Kari Alitalo, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku M. Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko J. T. Uutela