Abstract: A two step method of enhancing the cavitational effect produced by ultrasonic signals focused at a specific location in a medium includes a first step of using one or more transducers to apply the ultrasonic signals to create a waveform that causes formation of bubbles at the location, and a second step of modulating the amplitude of the ultrasonic signals at a frequency of several Hz to several tens of kilohertz immediately following or coincident with the formation of the bubbles.

Abstract: The present invention is a two step method of enhancing the cavitational effect produced by ultrasound signals focused at a specific location in a medium. The first step is to use one or more transducers to apply the ultrasound signals to create a waveform that causes formation of bubbles at the location and the second step is to modulate the amplitude of the ultrasound signals at a frequency of several Hz to several tens of kilohertz immediately following or coincident with the formation of the bubbles. The method of the invention can be effectively used for therapeutic purposes.