Patents Assigned to Ventria Bioscience
  • Patent number: 11492389
    Abstract: The present invention relates to cell culture media supplements or complete media compositions comprising plant-produced heterologous recombinant human albumin, as well as methods of making the cell culture media, and methods of using the supplemented cell culture media to improve viability, productivity, and growth characteristics of cultured cells.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: November 8, 2022
    Assignee: Ventria Biosciences Inc.
    Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
  • Patent number: 10981974
    Abstract: The present invention relates to cell culture media supplemented with a plant-produced recombinant mammalian albumin supplement, as well as methods of making the cell culture media, and methods of using the supplemented cell culture media to improve growth characteristics of cultured cells.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: April 20, 2021
    Assignee: Ventria Bioscience Inc.
    Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
  • Patent number: 10618951
    Abstract: The present invention relates to cell culture media containing combinations of proteins, as well as methods of making the cell culture media, and methods of using the cell culture media to improve growth characteristics of cultured cells.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: April 14, 2020
    Assignee: Ventria Biosciences Inc.
    Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
  • Publication number: 20160213766
    Abstract: Provided herein are monocot seed compositions and methods of making a monocot seed product expressing high levels of recombinant Osp fusion protein. In some embodiments, a rice seed composition is used in the manufacture of a Lyme disease vaccine formulation. In some embodiments, the composition comprising the Osp fusion protein is admixed with a drug or pharmacologically active agent, such as an antibiotic.
    Type: Application
    Filed: September 23, 2014
    Publication date: July 28, 2016
    Applicant: Ventria Bioscience, Inc.
    Inventors: Ning HUANG, Deshui ZHANG, Barbara J.B. JOHNSON, Chris MACMANUS
  • Patent number: 9321828
    Abstract: Disclosed are compositions and methods of making non-glycosylated transferrin protein in transgenic monocot plants.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: April 26, 2016
    Assignee: Ventria Bioscience Inc.
    Inventors: Deshui Zhang, Ning Huang, Diane Phuong Nguyen, Paula Bryan
  • Patent number: 8686225
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, as well as to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: April 1, 2014
    Assignee: Ventria Bioscience Inc.
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
  • Patent number: 8609416
    Abstract: Compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: December 17, 2013
    Assignee: Ventria Bioscience
    Inventor: Michael E. Barnett
  • Patent number: 8158857
    Abstract: The invention is directed to monocot plant seed products comprising human serum albumin, and to methods of making said monocot plant seed products comprising human serum albumin and to therapeutic compositions comprising them.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: April 17, 2012
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
  • Publication number: 20110189751
    Abstract: Compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures.
    Type: Application
    Filed: December 17, 2010
    Publication date: August 4, 2011
    Applicant: Ventria Bioscience
    Inventor: Michael E. Barnett
  • Patent number: 7718851
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 18, 2010
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Patent number: 7589252
    Abstract: The invention relates to transgenic plants that demonstrate enhanced expression of a plant transcription factor under the control of a seed specific promoter such that expression of the transcription factor activates transcription of a native or non-native coding sequence in the plant. The invention further relates to a method of generating such transgenic plants and methods for enhancing the level of expression of a selected heterologous protein in seeds of such transgenic plants.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: September 15, 2009
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Daichang Yang, Yong-Sic Hwang, Robert J. Schmidt
  • Publication number: 20080318277
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Application
    Filed: April 21, 2008
    Publication date: December 25, 2008
    Applicant: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Patent number: 7417178
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: August 26, 2008
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Patent number: 7304208
    Abstract: A method of producing human serum albumin (HSA) in monocot plant seeds, by transforming a monocot plant cell with a chimeric gene containing a promoter from the gene of a maturation-specific monocot plant storage protein, a first DNA sequence operably linked to the promoter and encoding a signal sequence, and a second DNA sequence linked in translation frame with the first DNA sequence and encoding HSA, where the first DNA sequence and the second DNA sequence together encode a fusion protein containing an N-terminal signal sequence and the HSA; growing a monocot plant from the transformed monocot plant cell for a time sufficient to produce seeds containing the HSA; and harvesting the seeds from the plant.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: December 4, 2007
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriquez, Frank E. Hagie, David M. Stalker
  • Patent number: 7138150
    Abstract: This invention concerns a method of making an anti-infective composition for oral administration using an agent selected from the group consisting of lactoferrin protein and lysozyme protein. The method comprises three steps. The nucleic acid, which encodes a lactoferrin or lysozyme protein, is expressed in a monocot seed. The protein is isolated from the seed. This protein isolation compromises greater than 3% of the total soluble protein in the monocot seed. The protein is then formulated for oral administration.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: November 21, 2006
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Jianmin Huang, Delia R. Bethell
  • Patent number: 6991824
    Abstract: The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: January 31, 2006
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Patent number: 6781044
    Abstract: A plant transformation vector for transforming host plant cells with a chimeric selectable marker gene is disclosed. The gene includes, operatively linked in sequence in a 5′ to 3′ direction, (i) a DNA promoter sequence from the rice beta-glucanase 9 (gns9) gene; (ii) a selectable marker gene, and (iii) a 3′ untranslated terminator region. Also disclosed are a vector pair containing the transformation vector, a method of obtaining transformed monocots whose seeds produce a selected heterologous protein during sed germination, and a plant whose cells are transformed with the chimeric selectable marker gene.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: August 24, 2004
    Assignee: Ventria Bioscience
    Inventors: Raymond L. Rodriguez, Ning Huang
  • Publication number: 20040111766
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Application
    Filed: August 12, 2003
    Publication date: June 10, 2004
    Applicant: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie