Patents Assigned to Ventria Bioscience
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Patent number: 11492389Abstract: The present invention relates to cell culture media supplements or complete media compositions comprising plant-produced heterologous recombinant human albumin, as well as methods of making the cell culture media, and methods of using the supplemented cell culture media to improve viability, productivity, and growth characteristics of cultured cells.Type: GrantFiled: June 7, 2022Date of Patent: November 8, 2022Assignee: Ventria Biosciences Inc.Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
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Patent number: 10981974Abstract: The present invention relates to cell culture media supplemented with a plant-produced recombinant mammalian albumin supplement, as well as methods of making the cell culture media, and methods of using the supplemented cell culture media to improve growth characteristics of cultured cells.Type: GrantFiled: April 13, 2020Date of Patent: April 20, 2021Assignee: Ventria Bioscience Inc.Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
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Patent number: 10618951Abstract: The present invention relates to cell culture media containing combinations of proteins, as well as methods of making the cell culture media, and methods of using the cell culture media to improve growth characteristics of cultured cells.Type: GrantFiled: June 21, 2016Date of Patent: April 14, 2020Assignee: Ventria Biosciences Inc.Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
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Publication number: 20160213766Abstract: Provided herein are monocot seed compositions and methods of making a monocot seed product expressing high levels of recombinant Osp fusion protein. In some embodiments, a rice seed composition is used in the manufacture of a Lyme disease vaccine formulation. In some embodiments, the composition comprising the Osp fusion protein is admixed with a drug or pharmacologically active agent, such as an antibiotic.Type: ApplicationFiled: September 23, 2014Publication date: July 28, 2016Applicant: Ventria Bioscience, Inc.Inventors: Ning HUANG, Deshui ZHANG, Barbara J.B. JOHNSON, Chris MACMANUS
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Patent number: 9321828Abstract: Disclosed are compositions and methods of making non-glycosylated transferrin protein in transgenic monocot plants.Type: GrantFiled: May 6, 2011Date of Patent: April 26, 2016Assignee: Ventria Bioscience Inc.Inventors: Deshui Zhang, Ning Huang, Diane Phuong Nguyen, Paula Bryan
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Patent number: 8686225Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, as well as to methods of making these isolated blood proteins and to therapeutic compositions comprising them.Type: GrantFiled: April 17, 2012Date of Patent: April 1, 2014Assignee: Ventria Bioscience Inc.Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
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Patent number: 8609416Abstract: Compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures.Type: GrantFiled: December 17, 2010Date of Patent: December 17, 2013Assignee: Ventria BioscienceInventor: Michael E. Barnett
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Patent number: 8158857Abstract: The invention is directed to monocot plant seed products comprising human serum albumin, and to methods of making said monocot plant seed products comprising human serum albumin and to therapeutic compositions comprising them.Type: GrantFiled: March 31, 2010Date of Patent: April 17, 2012Assignee: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
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Publication number: 20110189751Abstract: Compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures.Type: ApplicationFiled: December 17, 2010Publication date: August 4, 2011Applicant: Ventria BioscienceInventor: Michael E. Barnett
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Patent number: 7718851Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.Type: GrantFiled: April 21, 2008Date of Patent: May 18, 2010Assignee: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
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Patent number: 7589252Abstract: The invention relates to transgenic plants that demonstrate enhanced expression of a plant transcription factor under the control of a seed specific promoter such that expression of the transcription factor activates transcription of a native or non-native coding sequence in the plant. The invention further relates to a method of generating such transgenic plants and methods for enhancing the level of expression of a selected heterologous protein in seeds of such transgenic plants.Type: GrantFiled: March 16, 2005Date of Patent: September 15, 2009Assignee: Ventria BioscienceInventors: Ning Huang, Daichang Yang, Yong-Sic Hwang, Robert J. Schmidt
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Publication number: 20080318277Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.Type: ApplicationFiled: April 21, 2008Publication date: December 25, 2008Applicant: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
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Patent number: 7417178Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.Type: GrantFiled: August 12, 2003Date of Patent: August 26, 2008Assignee: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
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Patent number: 7304208Abstract: A method of producing human serum albumin (HSA) in monocot plant seeds, by transforming a monocot plant cell with a chimeric gene containing a promoter from the gene of a maturation-specific monocot plant storage protein, a first DNA sequence operably linked to the promoter and encoding a signal sequence, and a second DNA sequence linked in translation frame with the first DNA sequence and encoding HSA, where the first DNA sequence and the second DNA sequence together encode a fusion protein containing an N-terminal signal sequence and the HSA; growing a monocot plant from the transformed monocot plant cell for a time sufficient to produce seeds containing the HSA; and harvesting the seeds from the plant.Type: GrantFiled: April 11, 2003Date of Patent: December 4, 2007Assignee: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriquez, Frank E. Hagie, David M. Stalker
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Patent number: 7138150Abstract: This invention concerns a method of making an anti-infective composition for oral administration using an agent selected from the group consisting of lactoferrin protein and lysozyme protein. The method comprises three steps. The nucleic acid, which encodes a lactoferrin or lysozyme protein, is expressed in a monocot seed. The protein is isolated from the seed. This protein isolation compromises greater than 3% of the total soluble protein in the monocot seed. The protein is then formulated for oral administration.Type: GrantFiled: August 13, 2003Date of Patent: November 21, 2006Assignee: Ventria BioscienceInventors: Ning Huang, Jianmin Huang, Delia R. Bethell
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Patent number: 6991824Abstract: The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.Type: GrantFiled: February 14, 2002Date of Patent: January 31, 2006Assignee: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
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Patent number: 6781044Abstract: A plant transformation vector for transforming host plant cells with a chimeric selectable marker gene is disclosed. The gene includes, operatively linked in sequence in a 5′ to 3′ direction, (i) a DNA promoter sequence from the rice beta-glucanase 9 (gns9) gene; (ii) a selectable marker gene, and (iii) a 3′ untranslated terminator region. Also disclosed are a vector pair containing the transformation vector, a method of obtaining transformed monocots whose seeds produce a selected heterologous protein during sed germination, and a plant whose cells are transformed with the chimeric selectable marker gene.Type: GrantFiled: August 17, 2001Date of Patent: August 24, 2004Assignee: Ventria BioscienceInventors: Raymond L. Rodriguez, Ning Huang
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Publication number: 20040111766Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.Type: ApplicationFiled: August 12, 2003Publication date: June 10, 2004Applicant: Ventria BioscienceInventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie