Patents Assigned to VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS
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Patent number: 10174314Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.Type: GrantFiled: December 20, 2012Date of Patent: January 8, 2019Assignees: INTERNA TECHNOLOGIES B.V., VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: Rudolf Henrikus Brakenhoff, Marlon Van Der Plas, Sanne Rosaly De Kemp, Willemijn Maria Gommans, Grégoire Pierre André Prevost, Roeland Quirinus Jozef Schaapveld, Francesco Cerisoli
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Patent number: 10174365Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: GrantFiled: January 16, 2012Date of Patent: January 8, 2019Assignees: STICHTING VU-VUMC, VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: Thomas Wurdinger, Rolf Jonas Nilsson
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Patent number: 9315866Abstract: The inventors now have developed a (molecular) diagnostic marker based on MAL alterations, in particular reduced MAL mRNA and protein expression as well as MAL promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, and high-risk human papillomavirus (HPV)-induced precursor lesions of non-cervical invasive cancers within, cell material obtained via scraping, lavage or by other means and/or tissue. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the gene products thereof as marker for HPV-induced high-grade premalignant lesions, allowing early detection and better treatment option for the individual patient.Type: GrantFiled: April 14, 2009Date of Patent: April 19, 2016Assignee: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: Christophorus Joannes Lambertus Maria Meijer, Petrus Josephus Ferdinandus Snijders, Renske Daniëla Maria Steenbergen
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Patent number: 9297007Abstract: The current invention relates to use of particular nucleic acids for modulating (increasing or decreasing) blood-brain barrier function, and for use of such nucleic acids in treatment of conditions involving blood brain barrier function, including multiple sclerosis, HIV infection, Alzheimer's disease, Parkinson's disease, epilepsy, and so on. Also provided is an assay for identifying drugs useful in modulating blood brain barrier function.Type: GrantFiled: May 27, 2011Date of Patent: March 29, 2016Assignee: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: Arie Reijerkerk, Helga Eveline De Vries
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Patent number: 9290765Abstract: The invention relates to the field of endothelial barrier dysfunction, particular, the invention relates to new methods for the treatment of endothelial barrier dysfunction, such as inflammatory edema by inhibiting Abl-related gene (ARG).Type: GrantFiled: May 2, 2011Date of Patent: March 22, 2016Assignee: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORGInventors: Geerten P. van Nieuw Amerongen, Anton Vonk Noordegraaf, Jurjan Aman, Victor W. M. van Hinsbergh
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Publication number: 20140256590Abstract: The present invention relates to a method of analysing a blood sample of a subject carrying a foetus for the presence of a foetal disease or condition marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells, preferably thrombocytes, in said blood sample to provide an anucleated blood cell-extracted nucleic acid fraction, and b) analysing said anucleated blood cell-extracted nucleic acid fraction for the presence of a foetal disease or condition marker, wherein said foetal disease or condition marker is a nucleic acid of a foetus, or wherein said foetal disease or condition marker is a foetal disease or condition-specific expression profile of genes of a cell of said foetus.Type: ApplicationFiled: August 8, 2012Publication date: September 11, 2014Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJSInventors: Thomas Würdinger, Rolf Jonas Nilsson
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Publication number: 20140213788Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: Vereniging voor Christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorgInventors: Eelco RUIJTER, Romano ORRU, Anass ZNABET, Marloes POLAK, Nicholas TURNER
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Publication number: 20140187605Abstract: The invention relates to the field of endothelial barrier dysfunction, particular, the invention relates to new methods for the treatment of endothelial barrier dysfunction, such as inflammatory edema by inhibiting Abl-related gene (ARG).Type: ApplicationFiled: May 2, 2011Publication date: July 3, 2014Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORGInventors: Geerten P. van Nieuw Amerongen, Anton Vonk Noordegraaf, Jurjan Aman, Victor W. M. Hinsbergh
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Patent number: 8712762Abstract: During speech processing a filter adjusts a spectral envelope of an input speech signal with a frequency dependent adjustment factor. The adjustment factors for respective spectral components are selected dependent on the input speech signal. The factor is set to a first or second non-zero value, the second value being smaller than the first value, when a strength average for the spectral component is above and below a threshold value respectively.Type: GrantFiled: July 27, 2007Date of Patent: April 29, 2014Assignee: Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en PatiëntenzorInventors: Finn Dubbelboer, Tammo Houtgast
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Publication number: 20140114050Abstract: The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.Type: ApplicationFiled: March 14, 2013Publication date: April 24, 2014Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: JOHANNES GERHARDUS MARIA BOLSCHER, ARIE VAN NIEUW AMERONGEN, ENGELMUNDUS CORNELIS IGNATIUS VEERMAN, MENNO JOHANNES OUDHOFF, WILLEM VAN'T HOF, KAMRAN NAZMI, PETRONELLA ADRIANA MARIA VAN DEN KEIJBUS
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Patent number: 8686145Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.Type: GrantFiled: September 16, 2010Date of Patent: April 1, 2014Assignee: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg C/O Technology Transfer Officer VU & VumcInventors: Eelco Ruijter, Romano Orru, Anass Znabet, Marloes Polak, Nicholas Turner
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Patent number: 8670640Abstract: The invention provides an optical fiber, a method for the preparation thereof, and a device. An optical fiber, wherein a distal end of the optical fiber is provided with an optical mask adapted for projecting a predetermined pattern on a target surface by radiation transmitted from the distal end of the optical fiber, allows for the rapid application of patterns and three-dimensional structures on target surfaces, in particular on the ends of optical fibers.Type: GrantFiled: November 19, 2009Date of Patent: March 11, 2014Assignee: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en PatientenzorgInventors: Davide Iannuzzi, Audrius Petru{hacek over (s)}is, Jan Hendrik Rector
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Publication number: 20140038834Abstract: The present invention relates to a biomarker for the detection of brain damage or a disease associated with loss of neurons, said biomarker comprising a protein fragment of the neurofilament heavy chain (NfH) protein in a biological sample, wherein said protein fragment is a polypeptide selected from the group consisting of i) a polypeptide having the amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and polypeptides composed of amino acids 476-1026 and 476-986 of SEQ ID NO 6; ii) a protein fragment of the NfH protein having an amino acid sequence that is at least 60% identical to SEQ ID NO:1, at least 60% identical to SEQ ID NO:2, at least 60% identical to SEQ ID NO:3, at least 60% identical to SEQ ID NO:4, at least 60% identical to SEQ ID NO:5; or at least 60% identical to a polypeptide composed of amino acids 476-1026 and.Type: ApplicationFiled: July 7, 2011Publication date: February 6, 2014Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORGInventor: Axel Franz Siegfried Petzold
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Publication number: 20140030261Abstract: Described are methods for predicting a clinical response to B-lymphocyte inhibiting or depleting therapies (BCIDT) using expression levels of genes of the Type I INF pathway. In another aspect, the disclosure relates to a method for evaluating a pharmacological effect of a treatment with B-lymphocyte inhibiting or depleting therapy. More in particular, it relates to a method for prognosticating the clinical response of a patient to treatment with a soluble BCID or TCID agent, the method comprising the steps of obtaining at least two samples from the patient wherein a first sample has not been exposed to a soluble BCID or TCID agent and wherein at least a second sample has been exposed to a soluble BCID or TCID agent, determining the level of an IFN (preferably type I) response in the at least two samples, comparing the level of the IFN (preferably type I) response in the first sample with the level of the IFN (e.g.Type: ApplicationFiled: November 30, 2011Publication date: January 30, 2014Applicant: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En PatientenzorgInventor: Cornelis Lammert Verweij
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Patent number: 8629258Abstract: The present invention relates generally to the field of plant molecular biology and agents useful in the manipulation of plant physiological or biochemical properties. More particularly, the present invention provides genetic and proteinaceous agents capable of modulating or altering the level of acidity or alkalinity in a cell, group of cells, organelle, part or reproductive portion of a plant. Genetically altered plants, plant parts, progeny, subsequent generations and reproductive material including flowers or flowering parts having cells exhibiting an altered cellular pH compared to a non-genetically altered plant are also provided.Type: GrantFiled: May 28, 2007Date of Patent: January 14, 2014Assignees: Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg, Suntory Holdings LimitedInventors: Francesca Quattrocchio, Ronald Koes, Walter Verweij, Filippa Brugliera, Kees Spelt, Masako Mizutani
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Patent number: 8536321Abstract: Method for the detection of Chlamydia trachomatis, which method comprises the performance of a DNA amplification involving the use of a primer pair by using DNA that is derived from a sample as a template and the detection of an amplification product, characterized in that the primer pair used for the DNA amplification is designed on the basis of nucleotide sequences of the regions corresponding to the nucleotide numbers 3654 to 4320 and 4351 to 4448 in the nucleotide sequence of SEQ ID No. 1.Type: GrantFiled: February 6, 2008Date of Patent: September 17, 2013Assignee: Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patientenzorgInventors: Paul Hendrik Maria Savelkoul, Arnold Catsburg, Antonie Servaas Morre
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Patent number: 8530486Abstract: A compound of the formula (I) wherein X is CR1 or N; Y is CR3 or N; R1, R3, R4, R5 and R6 are independently H, F, Cl, Br, I, or a hydrocarbon group which optionally contains one or more heteroatoms; R7 is a heterocyclic group including one or more N atoms; R? is Rx or NRyRz wherein Rx, Ry and Rz are each H or the same or different groups, including cyclic groups formed by Ry and Rz with the N atom, of up to 20 C atoms and optionally including up to 3 further heteroatoms selected from N, O and S; or a pharmaceutically acceptable salt, ester or solvate thereof.Type: GrantFiled: January 2, 2009Date of Patent: September 10, 2013Assignee: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en PatientenzorgInventors: Rogier Adriaan Smits, Regorius Leurs, Iwan Jozef Philomena De Esch
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Publication number: 20120330015Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.Type: ApplicationFiled: September 16, 2010Publication date: December 27, 2012Applicant: Vereniging voor Christelijk hoger onderwijs, wetenschappelijk onderzoek en patientenzorgInventors: Eelco Ruijter, Romano Orru, Anass Znabet, Marloes Polak, Nicholas Turner
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Publication number: 20120329704Abstract: The present invention relates to a process for the stereoselective preparation of a compound having the general formula (I) or its respective diastereomers: comprising reacting a compound having the general formula (II) or its diastereomers: with a compound of the general formula III: R3—COOH and a compound of the general formula IV: R4—NC wherein R1 represents each independently, or jointly a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a hydrogen atom, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl, or an aromatic or non-aromatic aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure.Type: ApplicationFiled: September 16, 2010Publication date: December 27, 2012Applicant: Vereniging voor Christelijk hoger onderwijs wetenschappelijk onderzoek en patieentenzorgInventors: Eelco Ruijter, Romano Orru, Anass Znabet, Marloes Polak, Nicholas Turner
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Publication number: 20120295321Abstract: The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.Type: ApplicationFiled: November 12, 2010Publication date: November 22, 2012Applicants: Universiteit Utrecht Holding B.V., Universiteit Leiden, Stichting voor de Technische Wetenschappen, Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patientënzorgInventors: Patricia Ann vanKuyk, Ronald Peter de Vries, Jacob Visser, Arthur Franciscus Johannes Ram, Cornelis Antonius Maria Jacobus Johannes van den Hondel, Evy Battaglia, Diana Alexandra Vivas Duarte