Abstract: Methods for treating or prophylaxis of a cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.

Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.

Abstract: The present disclosure provides a distributed and anonymous approach to demand response of an electricity system. The approach conceptualizes energy consumption and production of distributed-energy resources (DERs) via discrete energy packets that are coordinated by a cyber computing entity that grants or denies energy packet requests from the DERs. The approach leverages a condition of a DER, which is particularly useful for (1) thermostatically-controlled loads, (2) non-thermostatic conditionally-controlled loads, and (3) bi-directional distributed energy storage systems. In a first aspect of the present approach, each DER independently requests the authority to switch on for a fixed amount of time (i.e., packet duration). The coordinator determines whether to grant or deny each request based electric grid and/or energy or power market conditions. In a second aspect, bi-directional DERs, such as distributed-energy storage systems (DESSs) are further able to request to supply energy to the grid.

Abstract: Systems and methods for distributing electric energy in discrete power packets of finite duration are presented. Systems may include an aggregator for providing power packets to one or more nodes. An aggregator may receive requests for power packets from nodes. In other embodiments, an aggregator may transmit status broadcasts and nodes may receive power packets based on the status broadcasts.

Abstract: The invention relates, in part, to compounds, compositions, and methods to assess molecular characteristics papillary microcarcinoma (PMC) of the thyroid and indicators of indolent compared to aggressive PMC of the thyroid. In addition, the invention relates, in part, to methods of assessing characteristics of microRNAs associated with PMC of the thyroid.

Abstract: Aspects of the present disclosure include anonymous, asynchronous, and randomized control schemes for distributed energy resources (DERs). Such control schemes may include packetized energy management (PEM) control schemes for managing DERs that may provide near-optimal tracking performance under imperfect information and consumer quality of service (QoS) constraints.

Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.

Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.

Abstract: Aspects of the present disclosure include anonymous, asynchronous, and randomized control schemes for distributed energy resources (DERs). Such control schemes may include packetized energy management (PEM) control schemes for managing DERs that may provide near-optimal tracking performance under imperfect information and consumer quality of service (QoS) constraints.

Abstract: Catheters, systems, and related methods for optimized for mapping, minimizing, and treating cardiac fibrillation in a patient, including an array of at least one stacked electrode pair, each electrode pair including a first electrode and a second electrode, wherein each electrode pair is configured to be orthogonal to a surface of a cardiac tissue substrate, wherein each first electrode is in contact with the surface to record a first signal, and wherein each second electrode is separated from the first electrode by a distance which enables the second electrode to record a second signal, wherein the catheter is configured to obtain one or more measurements from at least a first signal and a second signal in response to electrical activity in the cardiac tissue substrate indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across the cardiac tissue substrate.

Abstract: As described below, the present invention features methods for treating selected subjects at increased risk of a cardiovascular event, wherein the subjects are selected as having elevated platelet Fc?gamma RIIa.

Abstract: A device for moving the back and core muscles while sitting includes a rocking assembly that sits atop a base assembly, and optionally a height adjustment mechanism between the rocking assembly and the base assembly. The rocking assembly further includes a rocking mechanism that sits between a base plate or platform and a seat. The rocking mechanism can be, for example, a hollow or solid hemispheric- or dome-shaped rocking mechanism, an eccentric bicylinder rocking mechanism, and/or a rocking mechanism based on an arrangement of halfpipe members. The rocking mechanisms of the exercise chair allow to the seat to rock, wobble, and/or swivel with a side-to-side rocking motion, a front-to-back rocking motion, or both a side-to-side rocking motion and a front-to-back rocking motion.

Abstract: Self-stressing engineered composites that include a matrix containing self-stressing reinforcement that is activated by an activator that causes, in situ, the self-stressing reinforcement to transfer at least some of its pre-stress into portions of the matrix adjacent the self-stressing reinforcement. In some embodiments, the activator can be of a self-activating, an internal activating, and/or an external activating type. In some embodiments, the self-stressing reinforcement includes an active component that holds and transfers pre-stress to a matrix and a releasing component that causes the active component to transfer its pre-stress to the matrix. In some embodiments, the self-stressing reinforcement is initially unstressed and becomes stressed upon activation. Various engineered composites, self-stressing reinforcement, and applications of self-stressing engineered composites are disclosed.

Abstract: An improved Ground Penetrating Radar (GPR) system is provided. The system advantageously employs full waveform digitization of a returning signal to significantly reduce the number of launch signals and allowing the amount of radiation emitted to stay within the limit set by the Federal Communications Commission (FCC), while producing a robust information detection signal. In addition, intermittent large latent-duty-cycle sampling employs a less expensive digitizer typically used in prior art GPRs. The system is scalable at low-cost to accommodate multi-antenna multi-static testing for subsurface tomographic imaging.

Abstract: Systems and methods for determining lung recruitment/derecruitment dynamics of an individual are disclosed. The disclosed embodiments advantageously use variable ventilation of the individual to determine lung dynamics without necessitating additional, potentially harmful ventilation maneuvers.