Abstract: The invention provides a container for a sample comprising a hollow body having a base, a side wall and an open end opposite the base, a closure for that body, the closure being arranged to fit to the body to close the open end thereof; and locking means for locking the closure to the body, in such fashion that the contents of the container cannot be removed without it being apparent on subsequent observation of the container. Preferably said closure is provided with a tear-off portion defined thereon by a line of weakness in the material of the closure, removal of the tear-off portion by tearing along said line of weakness allowing removal of the sample from the body.