Patents Assigned to Versicor, Inc.
  • Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
    Patent number: 6541276
    Abstract: A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: April 1, 2003
    Assignee: Versicor, Inc.
    Inventors: Dinesh V. Patel, Khehyong Ngu
  • Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
    Patent number: 6448058
    Abstract: Methods of preparing combinatorial libraries of mercapto (thiol) compounds them and compositions obtained therefrom are disclosed. The compounds are synthesized on a solid support. Following synthesis, the compounds are optionally cleaved from the support. One such method of synthesis involves attack of an S-protected nucleophile on a resin functionalized with a leaving group. The invention also provides for screening the mercapto compounds for bioactive compounds; in particular, for inhibitors of MMPs.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: September 10, 2002
    Assignee: Versicor, Inc.
    Inventors: Dinesh V. Patel, Khehyong Ngu, Jianping Zhou
  • Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
    Patent number: 6413724
    Abstract: The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of bioactive, fused 2,4-pyrimidinediones from those libraries.
    Type: Grant
    Filed: February 4, 1997
    Date of Patent: July 2, 2002
    Assignee: Versicor, Inc.
    Inventors: Mikhail F. Gordeev, Dinesh V. Patel
  • Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
    Patent number: 6281245
    Abstract: A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: August 28, 2001
    Assignee: Versicor, Inc.
    Inventors: Dinesh V. Patel, Khehyong Ngu
  • Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
    Patent number: 6025371
    Abstract: The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of bioactive, fused 2,4-pyrimidinediones from those libraries.
    Type: Grant
    Filed: October 28, 1996
    Date of Patent: February 15, 2000
    Assignee: Versicor, Inc.
    Inventors: Mikhail F. Gordeev, Dinesh V. Patel
  • Synthesis of substituted N-heteroaromatic compounds and methods of use thereof
    Patent number: 5886186
    Abstract: The subject invention features substituted N-heteroaromatic compounds, libraries of substituted N-heteroaromatic compounds, and methods of synthesis thereof. For example, the present invention provides methods for synthesizing substituted N-heteroaromatic compounds, and is particularly amenable to the generation of libraries of substituted N- heteroaromatic compounds by combinatorial chemistry. The methods of the invention generally feature the reaction of O-linked heteroaromatic N-oxides with nucleophiles to produce substituted N-heteroaromatic compounds.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: March 23, 1999
    Assignee: Versicor, Inc.
    Inventors: Robert L. Smith, Gnanasambandam Kumaravel, Donald E. Kuhla
  • Reversible charge-based sequestration on solid support
    Patent number: 5605616
    Abstract: Methods for reversibly associating a substrate compound and a solid support are described. In general, the methods feature the use of selectively chargeable moieties. Apparatus for use with the methods of the invention is also described.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: February 25, 1997
    Assignee: VersiCor, Inc.
    Inventor: Charles M. Zepp