Patents Assigned to Vertex Phamaceuticals Incorporated
  • Compounds useful as protein kinase inhibitors
    Patent number: 8557818
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: October 15, 2013
    Assignee: Vertex Phamaceuticals Incorporated
    Inventors: Jean-Damien Charrier, Ronald Knegtel, David Kay
  • PREPARATION OF PROTECTED ALPHA-KETO BETA-AMINO ESTERS AND AMIDES
    Publication number: 20130131356
    Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
    Type: Application
    Filed: January 7, 2013
    Publication date: May 23, 2013
    Applicant: VERTEX PHAMACEUTICALS INCORPORATED
    Inventor: VERTEX PHAMACEUTICALS INCORPORATED
  • SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID
    Publication number: 20110263654
    Abstract: The present invention relates to a substantially a solid form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1, Solvate Form A and Compound 1, HCl Salt Form A), processes for making such forms, pharmaceutical compositions thereof, and methods of treatment therewith.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 27, 2011
    Applicant: Vertex Phamaceuticals Incorporated
    Inventors: Ali Keshavarz-Shokri, Beili Zhang, Mariusz Krawiec