Abstract: The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
Type:
Application
Filed:
October 22, 2010
Publication date:
April 28, 2011
Applicant:
Vertex Pharmaceuticals Incorported
Inventors:
Fredrick F. Van Goor, William Lawrence Burton