Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
Type:
Grant
Filed:
October 5, 2001
Date of Patent:
March 4, 2003
Assignee:
Vertex Pharmacuticals, Incorporated
Inventors:
Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal