Abstract: Improved feeding set connectors and cassettes are disclosed for use with peristaltic infusion pumps for safely delivering enteral nutritional fluids to a patient. The connectors provide an easy to use “pump-to-set” integration or “keying” system for specific reusable infusion pumps and their matching feeding sets, and can be utilized by medical professionals having various skill levels. The inventive feeding set cassettes can prevent accidental free flow of enteral fluids into a patient, even upon inadvertent release of the connector from the pumping mechanism.