Abstract: Described herein is an instrument, comprising a staple body and a supporting body hingedly connected thereto, both having longitudinal jaws. The staple body has staple magazines and a staple ejector. The supporting body has a die for bending the staples when suturing. A recess is provided at the base of one of the jaws on the side facing the hinge joint interconnecting the instrument bodies, the recess defining a free space between the jaws when they are brought together. The jaws are adapted to have springy elastic spacers mounted and held thereon with a possibility of subsequent releasing therefrom, said spacers being arranged on the side facing the inner compressing surfaces of the jaws so as to be stitched up together with the organs being sutured.The instrument disclosed in the present invention is successfully applied for establishing lateral anastomoses and interintestinal compression anastomoses, as well as for stitching up the mesentery.