Patents Assigned to Veteran
  • Expansion of Interferon-Gamma-Producing T-Cells Using Glypican-3 Peptide Library
    Publication number: 20130217122
    Abstract: The present invention encompasses a method for expanding an antigen specific T cell from a population of cells. The method of the present invention comprises contacting a population of cells with an MHC restricted antigenic glypican-3 peptide. In some instances, the T cell is expanded using monocyte-derived dendritic cells and defined MHC restricted antigenic glypican-3 peptides. In one embodiment, high-affinity antigen-specific T-cell receptors (TCRs) can be cloned from the antigen specific T cell.
    Type: Application
    Filed: February 21, 2013
    Publication date: August 22, 2013
    Applicants: The Trustees of the University of Pennsylvania, Veteran
    Inventors: The Trustees of the University of Pennsylvania, Government of the United States of America as Represented by the Secretary of the Department of Veteran