Abstract: In some aspects, provided herein are compositions of and methods for utilizing a sterically stabilized liposome carrier encapsulating a selected drug for the delivery of such drug effectual in the treatment of a mammal infected by a virus, such as SARS-COV-2, specifically in inhibiting the viral replication and reducing symptoms including lung inflammation. The compositions and methods disclosed herein provide a potential treatment for COVID-19 with improved patient compliance as they offer a less frequent dosing for the “long haulers” post COVID-19 initial infection.
Type:
Grant
Filed:
March 13, 2023
Date of Patent:
October 7, 2025
Assignee:
VGSK Technologies, Inc.
Inventors:
Kameswari S. Konduri, Ram Pattisapu, Jogi Pattisapu, John Zwetchkenbaum
Abstract: Disclosed herein are pharmaceutical compositions and methods for oral or sublingual administration comprising sterically stabilized liposome carriers which release in different pHs in a subject. Compositions and methods for treatment of allergies, eosinophilic esophagitis, inflammation, tuberculosis and other diseases are also described.
Type:
Grant
Filed:
January 3, 2024
Date of Patent:
March 18, 2025
Assignee:
VGSK Technologies, Inc.
Inventors:
Kameswari S. Konduri, Nejat Duzgunes, Jogi Pattisapu, Ram Pattisapu
Abstract: The application disclosure provides a sterically stabilized liposome carrier encapsulating a selected drug for the aerosol delivery of the drug effectual in the treatment of a mammal, a composition containing the sterically stabilized liposome carrier and the selected drug effective for the treatment of airway hypersensitivity and inflammation such as of the lungs of a mammal as an aerosol, and a method of treatment using the composition. The composition disclosed herein provides effective treatment for the longer of a period of time at least twice as long as the selected drug alone or up to at least one week.
Type:
Grant
Filed:
April 23, 2020
Date of Patent:
May 10, 2022
Assignee:
VGSK Technologies, Inc.
Inventors:
Kameswari S. Konduri, Sandhya N. Nandedkar, Nejat Duzgunes, Pattisapu Ram Jogi Gangadharam
Abstract: This invention comprises a sterically stabilized liposome carrier encapsulating a selected drug for the aerosol delivery of the drug effectual in the treatment of the lungs of a mammal, a composition containing the sterically stabilized liposome carrier and the selected drug effective for the treatment of the lungs of a mammal for asthma and inflammation of the lungs of the mammal as an aerosol and a method of, treatment using the composition. The composition provides effective treatment for the longer of a period of time at least twice as long as the selected drug alone or up to at least one week.
Type:
Grant
Filed:
July 18, 2008
Date of Patent:
September 30, 2014
Assignee:
VGSK Technologies, Inc.
Inventors:
Kameswari S. Konduri, Sandhya Nandedkar, Nejat Duzgunes, Ramakrishna Pattisapu