Patents Assigned to Via Ariosto, 23
  • BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS
    Publication number: 20080113993
    Abstract: This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1$g(a) and p300) and thereby inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer.
    Type: Application
    Filed: January 16, 2008
    Publication date: May 15, 2008
    Applicant: Via Ariosto, 23
    Inventors: Jackie DE BELIN, Maria-Rosario Romero-Martin, Paul Finn, Lee Sayers, Norman Law, David Billington, Stephen Ryley, Shoumo Bhattacharya