Abstract: Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood, e.g., umbilical cord blood. In some cases a growth factor is administered with the cells.
Type:
Grant
Filed:
October 27, 2000
Date of Patent:
October 12, 2010
Assignees:
Viacell, Inc., The General Hospital Corp.
Inventors:
Morey Kraus, Seth Finklestein, Paul Clark
Abstract: The present invention features methods of organ tissue regeneration using pluripotent cells derived from umbilical cord blood, compositions of these pluripotent cells, methods for further transforming these cells, and uses for these transformed cells.
Type:
Application
Filed:
December 20, 2004
Publication date:
July 16, 2009
Applicant:
Viacell, Inc.
Inventors:
Morey Kraus, Marc D. Beer, Paul T. Clark
Abstract: The invention features methods for treating a patient suffering from muscular dystrophy by administration of umbilical cord blood cells, e.g., by IV infusion.
Type:
Application
Filed:
November 18, 2008
Publication date:
March 12, 2009
Applicant:
Viacell, inc.
Inventors:
Robert H. Brown, JR., Seth P. Finklestein, Morey Kraus
Abstract: The invention features methods for treating a patient suffering from muscular dystrophy by administration of umbilical cord blood cells, e.g., by IV infusion.
Type:
Grant
Filed:
July 23, 2002
Date of Patent:
November 18, 2008
Assignees:
Viacell, Inc., The General Hospital Corporation
Inventors:
Robert H. Brown, Jr., Seth P. Finklestein, Morey Kraus
Abstract: Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.
Type:
Grant
Filed:
December 6, 2000
Date of Patent:
March 15, 2005
Assignee:
Viacell, Inc.
Inventors:
Joel F. Habener, Henryk Zulewski, Elizabeth Abraham, Mario Vallejo, Denise L. Faustman, Melissa K. Thomas
Abstract: The present invention features methods of modulating primary stem cell differentiation in culture by altering the endogenous activity of an insulin-like growth factor.
Abstract: Methods are provided for expanding populations of non-fetal hemangioblasts, for example a method including (a) providing a first cell population containing non-fetal hemangioblasts; and (b) growing the enriched cell culture under conditions that promote the proliferation of the non-fetal hemangioblasts. Preferred populations include non-fetal uncommitted human hemangioblasts.