Abstract: Methods for storing or rejuvenating blood involve contacting blood with a blood storage composition or a blood rejuvenating composition that include D-ribose and a nucleoside other than inosine (e.g., guanosine).
Abstract: Blood storage and/or rejuvenating compositions that include D-ribose and an arginine (e.g. L-arginine, D-arginine, or a combination thereof) are disclosed herein. Such compositions can be useful in methods for treating (e.g., storing and/or rejuvenating) red blood cells.
Abstract: A ribose-related compound is added to whole blood or packed red cells which have suboptimal function as measured by decreased levels of 2,3-DPG in order to rejuvenate the red blood cells to normal function as seen by raised levels of 2,3-DPG. Two representative ribose-related compounds are D-ribose and inosine.
Type:
Grant
Filed:
January 5, 2007
Date of Patent:
June 24, 2014
Assignee:
Viacell, LLC
Inventors:
John A St. Cyr, Daniel G Ericson, Clarence A Johnson
Abstract: D-Ribose, a buffer and an anticoagulant are added to whole blood or packed red cells to extend function in storage beyond 42 days. Methods are disclosed to rejuvenate suboptimally functional red cells. The methods are comprised of incubation of the cells at 37° C. for 10 to 60 minutes in the presence of D-ribose.
Type:
Grant
Filed:
May 14, 2003
Date of Patent:
March 30, 2010
Assignee:
Viacell, LLC.
Inventors:
John A. St. Cyr, Daniel G. Ericson, Clarence A. Johnson
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