Abstract: A transdermal system for providing estrogen to a patient in need thereof is provided. The transdermal system comprises a backing, and a matrix contacting the backing, the matrix configured to release about 4 meg per day to about 36 meg per day of an estrogen to the patient. This application also provides methods of providing estrogen to a patient in need thereof. The methods described in this application comprise applying to the skin of the patient a transdermal system comprising a backing, and a matrix contacting the backing, the matrix configured to release about 4 meg per day to about 36 meg per day of an estrogen to the patient.