Abstract: A brain interaction apparatus is provided. The apparatus comprises a plurality of filaments; and a brain invasive launcher having a plurality of launching channels extending in a longitudinal direction between a proximal end and a distal end thereof. Each launching channel is configured for holding one of the plurality of filaments moveably arranged therein. At least one of the plurality of filaments is provided with a steering tip affixed to a distal end thereof. The steering tip comprises a portion tapering in a longitudinal direction of the at least one of the plurality of filaments thereby narrowing toward a distal end of the steering tip. The tapered portion is rotationally asymmetrical about a longitudinal axis of the at least one of the plurality of filaments.

Abstract: A brain interaction apparatus is provided. The apparatus comprises a plurality of filaments; and a brain invasive launcher having a plurality of launching channels extending in a longitudinal direction between a proximal end and a distal end thereof. Each launching channel is configured for holding one of the plurality of filaments moveably arranged therein. At least one of the plurality of filaments is provided with a steering tip affixed to a distal end thereof. The steering tip comprises a portion tapering in a longitudinal direction of the at least one of the plurality of filaments thereby narrowing toward a distal end of the steering tip. The tapered portion is rotationally asymmetrical about a longitudinal axis of the at least one of the plurality of filaments.

Abstract: A kit of parts for electrical stimulation and/or recording of activity of excitable cells in a tissue is described. The kit of parts comprises on the one hand a probe guiding means comprising a plurality of accommodation channels, each channel being adapted for accommodating a probe device having a plurality of stimulation means and/or recording means located on a die. At least one of the plurality of accommodation channels has a curved shape. The kit of parts also comprises at least one probe device for electrical stimulation and/or recording of activity of excitable cells in a tissue, the probe device comprising a plurality of stimulation means and/or recording means located on a die having a thinned and etched surface for providing flexibility to the probe device.

Abstract: The present disclosure provides a device for analyzing target molecules. The device comprises a substrate retention device for holding a substrate having a functionalized surface provided thereon. This functionalized surface is adapted for capturing a plurality of target molecules. The device also comprises a light source for illuminating the functionalized surface and an image sensor for recording interference patterns of magnetic particles present on the functionalized surface. The device further comprises a first magnetic field generator configured to generate a magnetic field to attract magnetic particles linked to the target molecules to the functionalized surface. The disclosure further relates to a method for analyzing target molecules.

Abstract: The invention provides methods and kits to detect liver fibrosis or a change in the gradation of liver fibrosis in mammals. The diagnostic marker is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum.