Patents Assigned to VIB
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Patent number: 11975078Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.Type: GrantFiled: July 9, 2020Date of Patent: May 7, 2024Assignees: Universiteit Gent, VIB VZW, VRIJE Universiteit BrusselInventors: Thierry Vandendriessche, Marinee Chuah, Pieter De Bleser
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Patent number: 11964002Abstract: The present invention relates to the field of recombinant protein production in a host cell. More specifically the invention relates to the field of oral protein delivery. Specifically, the invention provides oral pharmaceutical formulations comprising the culture medium of a recombinant host secreting a recombinant protein. The resulting oral pharmaceutical formulations are useful for the treatment of gastro-intestinal and/or buccal disorders. Additionally, the oral pharmaceutical formulations are useful for prophylactic and vaccine purposes.Type: GrantFiled: February 28, 2018Date of Patent: April 23, 2024Assignees: VIB VZW, Universiteit GentInventors: Nico Callewaert, Robin Vanluchene, Bram Laukens, Anna Depicker, Vikram Virdi
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Patent number: 11945840Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.Type: GrantFiled: March 18, 2021Date of Patent: April 2, 2024Assignees: VIB VZW, Vrije Universiteit Brussel, Oxford Nanopore Technologies PLCInventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, John Joseph Kilgour
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Patent number: 11939586Abstract: The present invention relates to the field of plant genetic engineering, particularly the modulation of gene expression in plant cells for improved regeneration competence. The invention discloses means and methods wherein the Ethylene Response Factor (ERF) and Phytochrome A Signal Transduction 1 (PAT1) transcription factor complex activity in plant cells grants increased regeneration.Type: GrantFiled: October 11, 2017Date of Patent: March 26, 2024Assignees: VIB VZW, Universiteit GentInventors: Lieven De Veylder, Jefri Heyman
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Patent number: 11931160Abstract: A brain interaction apparatus is provided. The apparatus comprises a plurality of filaments; and a brain invasive launcher having a plurality of launching channels extending in a longitudinal direction between a proximal end and a distal end thereof. Each launching channel is configured for holding one of the plurality of filaments moveably arranged therein. At least one of the plurality of filaments is provided with a steering tip affixed to a distal end thereof. The steering tip comprises a portion tapering in a longitudinal direction of the at least one of the plurality of filaments thereby narrowing toward a distal end of the steering tip. The tapered portion is rotationally asymmetrical about a longitudinal axis of the at least one of the plurality of filaments.Type: GrantFiled: May 31, 2018Date of Patent: March 19, 2024Assignees: Imec vzw, Katholieke Universiteit Leuven, VIBInventors: Sebastian Haesler, Luis Diego Leon Hoffman
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Patent number: 11891451Abstract: The present invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Specifically, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.Type: GrantFiled: May 9, 2018Date of Patent: February 6, 2024Assignees: VIB VZW, Universiteit GentInventors: Nico Callewaert, Bram Laukens, Loes Van Schie, Wander Van Breedam, Wim Nerinckx
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Patent number: 11872262Abstract: The present invention relates to non-naturally occurring anti-bacterial peptides. More specifically the peptides can be used to treat multi-drug resistant bacterial infections. In addition, the present invention provides methods for producing anti-bacterial peptides.Type: GrantFiled: May 9, 2018Date of Patent: January 16, 2024Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&DInventors: Joost Schymkowitz, Frederic Rousseau
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Patent number: 11873347Abstract: The present invention relates to the field of structural biology. More specifically, the present invention relates to novel antigen-binding chimeric proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use as a therapeutic, diagnostic, or imaging tool. Even more specifically, the invention relates to a fusion of a scaffold protein and an antigen-binding domain wherein the scaffold protein of said fusion interrupts the Immunoglobulin domain topology to form a rigid chimer.Type: GrantFiled: October 31, 2018Date of Patent: January 16, 2024Assignees: VIB VZW, VRIJ UNIVERSITEIT BRUSSELInventors: Jan Steyaert, Els Pardon, Tomasz Uchanski, Wim Vranken
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Patent number: 11814688Abstract: The present application relates to the field of cancer, particular to hypoxic tumors. It was found that hypoxia is an important driver for hypermethylation of (promoters of) tumor suppressor genes. As this hypermethylation is a stable signature that is also present in circulating tumor DNA in peripheral blood, detecting this methylation pattern is a surrogate marker for tumor hypoxia. This can be used to adapt therapy as well.Type: GrantFiled: April 25, 2022Date of Patent: November 14, 2023Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R & D, Life Sciences Research Partners VZWInventors: Diether Lambrechts, Bernard Thienpont
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Patent number: 11713354Abstract: The present invention relates to antagonists, particularly antibodies and antigen binding fragments thereof, that bind to the protein galectin-10, particularly human galectin-10. The galectin-10 antagonists disrupt the crystallization of galectin-10 and are therefore useful in methods of preventing and treating diseases and conditions wherein the pathology is linked to the formation/presence of Charcot-Leyden crystals (CLCs).Type: GrantFiled: March 8, 2021Date of Patent: August 1, 2023Assignees: ARGENX BV, VIB VZW, Universiteit GentInventors: Jean-Michel Percier, Christophe Blanchetot, Michael Saunders, Hans De Haard, Sebastian Van Der Woning, Emma Persson, Bart Lambrecht, Savvas Savvides, Hamida Hammad, Kenneth Verstraete
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Patent number: 11702477Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.Type: GrantFiled: November 7, 2016Date of Patent: July 18, 2023Assignees: Orionis Biosciences BV, VIB VZW, Universiteit GentInventors: Nikolai Kley, Jan Tavernier, Leander Huyghe, Thomas Wueest
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Publication number: 20230221329Abstract: The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses means and methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agent. Said cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics of said reaction.Type: ApplicationFiled: August 5, 2022Publication date: July 13, 2023Applicants: VIB VZW, Universiteit GentInventors: Nico Callewaert, Sven Eyckerman, Simon Devos
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Patent number: 11692187Abstract: The present invention relates to novel nucleic acid sequences encoding bacterial xylose isomerases that upon transformation of a eukaryotic microbial host cell, such as yeast, to confer to the host cell the ability of isomerising xylose to xylulose. The nucleic acid sequences encode xylose isomerases that originate from bacteria such as Eubacterium sp., Clostridium cellulosi and others. The invention further relates to fermentation processes wherein the transformed host cells ferment a xylose-containing medium to produce ethanol or other fermentation products.Type: GrantFiled: December 21, 2017Date of Patent: July 4, 2023Assignees: VIB vzw, Katholieke Universiteit Leuven, K.U. Leuven R&D, GlobalYeast N.V.Inventors: Johan Thevelein, Mekonnen Demeke, Maria Remedios Foulquié Moreno, Stijn De Graeve, Edgard Valdomiro Charles Belo
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Patent number: 11661455Abstract: The present invention relates, in part, to chimeric proteins that find use in various immunotherapies. Particularly, the present invention provides targeted therapeutic agents that modulate the immune system for the treatment of diseases such as cancer.Type: GrantFiled: February 6, 2017Date of Patent: May 30, 2023Assignees: Orionis Biosciences BV, VIB VZW, Universiteit GentInventors: Jan Tavernier, Nikolai Kley
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Patent number: 11654201Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.Type: GrantFiled: October 21, 2019Date of Patent: May 23, 2023Assignees: VIB VZW, Universiteit Gent, Life Sciences Research Partners VZWInventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
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Patent number: 11649508Abstract: The present invention relates to the field of inflammation-associated disorders or conditions, more particularly to gut inflammation. Provided herein are means and methods to diagnose and treat or reduce the severity of inflammation-associated disorders or conditions in a subject in need thereof.Type: GrantFiled: December 14, 2018Date of Patent: May 16, 2023Assignees: VIB VZW, KATHOLIEKE UNIVERSITES LEUVEN, K.U.LEUVEN R & D, VRIJE UNIVERSITES BRUSSELInventors: Jeroen Raes, Gwen Falony, Mireia Valles-Colomer, Lindsay Devolder, Severine Vermeire, Sara Vieira-Silva, João Guedelha Sabino, Marie D'Hooghe, Jacques De Keyser
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Publication number: 20230079731Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.Type: ApplicationFiled: September 16, 2022Publication date: March 16, 2023Applicants: VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, OXFORD NANOPORE TECHNOLOGIES PLCInventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
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Patent number: 11573238Abstract: The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the reaction kinetics.Type: GrantFiled: September 28, 2018Date of Patent: February 7, 2023Assignees: VIB VZW, Universiteit GentInventors: Nico Callewaert, Sven Eyckerman, Simon Devos
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Patent number: 11572387Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.Type: GrantFiled: July 2, 2018Date of Patent: February 7, 2023Assignees: VIB VZW, Vrije Universiteit Brussel, Oxford Nanopore Technologies PLCInventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
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Patent number: 11478499Abstract: A non-surgical treatment of cataract in a human or animal. The invention specifically relates to the administration of a deglycating enzyme and its cofactor(s), which results in the deglycation of the lens crystallins. The disclosure thus relates to a minimal invasive type of treatment of cataract, which is easier and cheaper compared to existing surgical methods.Type: GrantFiled: January 28, 2019Date of Patent: October 25, 2022Assignees: Universiteit Gent, VIB VZWInventors: Elisabeth Van Aken, Joris Delanghe, Nico Callewaert, Loes Van Schie