Patents Assigned to VIB
  • Mutant CsgG pores
    Patent number: 10400014
    Abstract: The invention relates to mutant forms of the outer membrane-located lipoprotein CsgG, in particular, modifications at one or more of positions Tyr51; Asn55; and Phe56. The invention also relates to analyte detection and characterisation using said mutant CsgG.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 3, 2019
    Assignees: Oxford Nanopore Technologies Ltd., VIB VZW, Vrije Universiteit Brussel
    Inventors: Stefan Howorka, Han Remaut, Lakmal Jayasinghe, Elizabeth Jayne Wallace, James Anthony Clarke, Richard George Hambley, Jonathan Bankes Pugh
  • Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
    Patent number: 10392609
    Abstract: Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: August 27, 2019
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent, Vrije Universiteit Brussel
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Petra Sophie Tiels, Han Karel Remaut, Kathleen Camilla Telesphore Alida Maria Piens
  • SPHINGAMIDE COMPOUNDS AND METHODS FOR BINDING iNKT CELLS
    Publication number: 20190256541
    Abstract: The compounds, compositions and methods provided herein antagonize, inhibit, decrease, reduce, suppress, or disrupt CD1d-mediated, iNKT cell-mediated, and/or iNKT cell TCR-mediated immune signaling. The sphingamide compounds were rationally designed based upon 3D structural considerations in relation to the structures of each of CD1d, the iNKT cell TCR, and the ternary complex CD1d-a-GalCer analog lipids-TCR. More specifically, the addition of an amide in the phytosphingosine tail of a derivative of ?-GalCer led to a non-conserved binding with CD1d, a conserved binding with the iNKT cell TCR, and an antagonist-like phenotype.
    Type: Application
    Filed: November 14, 2016
    Publication date: August 22, 2019
    Applicants: La Jolla Institute for Allergy and Immunology, Universiteit Gent, VIB VZW
    Inventors: Dirk Zajonc, Serge Van Calenbergh, Dirk Elewaut, Joren Guillaume
  • Virus-like particle (VLP) based small molecule-protein interaction trap
    Patent number: 10379115
    Abstract: This disclosure relates to a virus-like particle in which a small molecule-protein complex is entrapped, ensuring the formation of the small molecule-protein complex under physiological conditions, while protecting the small molecule-protein complex during purification and identification. The disclosure further relates to the use of such virus-like particle for the isolation and identification of small molecule-protein complexes.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 13, 2019
    Assignees: Universiteit Gent, VIB VZW
    Inventors: Jan Tavernier, Sven Eyckerman
  • Single domain antibodies capable of modulating BACE activity
    Patent number: 10377834
    Abstract: Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: August 13, 2019
    Assignees: VIB VZW, KATHOLIEKE UNIVERSITEIT LEUVEN. K.U. LEUVEN R&D, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Bart De Strooper, Els Marjaux, Lujia Zhou, Serge Muyldermans
  • Means and methods for regulating secondary metabolite production in plants
    Patent number: 10370672
    Abstract: This disclosure relates to the field of secondary metabolite production in plants. More specifically, the disclosure relates to chimeric genes and their use in the regulation of biosynthesis and/or production of secondary metabolites in plants and plant-derived cell cultures.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: August 6, 2019
    Assignees: VIB XVZW, UNIVERSITEIT GENT, UNIVERSITEIT LEIDEN
    Inventors: Alain Goossens, Jan Mertens, Alex Van Moerkercke, Jacob Pollier, Johan Memelink
  • Therapeutic Agents for Neurological and Psychiatric Disorders
    Publication number: 20190225662
    Abstract: The present invention relates to the field of disorders of the central nervous system, in particular neurological and psychiatric disorders, and the prevention and/or treatment thereof. In particular, the present invention relates to the finding that soluble amyloid precursor protein ? (sAPP?) presents a particular binding site, which allows for binding to the GABABR1a receptor, thereby causing an agonistic effect through specific binding to Sushi domain 1 of GABABR1a. As a result, the frequencies of excitatory and inhibitory postsynaptic currents are reduced. Accordingly, the invention provides compounds able to interfere with the association of sAPP? with Sushi domain 1 of GABABR1a and as such with selective impairment of GABABR1a beneficial in neurological and psychiatric disorders. The invention as well provides methods and (high content) screening assays for the production of said compounds.
    Type: Application
    Filed: July 14, 2017
    Publication date: July 25, 2019
    Applicants: VIB VZW, Katholieke Universiteit Leuven, K.U.Leuven R&D
    Inventors: Joris DE WIT, Heather RICE, Bart DE STROOPER
  • De-mannosylation of phosphorylated N-glycans
    Patent number: 10344310
    Abstract: Methods for demannosylating phosphorylated N-glycans on a glycoprotein are described that use a mannosidase capable of hydrolyzing a terminal alpha-1,2 mannose linkage when the underlying mannose is phosphorylated.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: July 9, 2019
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken
  • Means and methods for mediating protein interference
    Patent number: 10336791
    Abstract: The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in agrobiotech applications.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: July 2, 2019
    Assignees: VIB VZW, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Joost Schymkowitz, Frederic Rousseau
  • Membrane span-kinase fusion protein and the uses thereof
    Patent number: 10336811
    Abstract: The disclosure relates to a recombinant membrane span protein complex, comprising (1) a fusion protein, comprising a membrane span protein fused to a kinase domain, preferably a constitutive kinase and (2) a reporter construct comprising a polypeptide, interacting with the membrane span protein, fused to a reporter phosphorylation domain. The disclosure relates further to the uses of such membrane span protein complex for the detection of compounds that interact with the membrane span protein and for the screening and/or detection of inhibitors of the compound-membrane span protein interactions. In a preferred embodiment, the membrane span protein is a G protein coupled receptor (GPCR) and the method is used for the screening and/or detection of inhibitors of the ligand-receptor binding.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: July 2, 2019
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Jan Tavernier, Samuel Lievens
  • Microsatellite instability markers in detection of cancer
    Patent number: 10294529
    Abstract: The present application relates to the field of cancer, particularly to mismatch repair (MMR?) deficient tumors. New markers are presented herein that have a high sensitivity to detect whether a tumor is mismatch repair deficient or not. The markers are particularly mutations in microsatellite regions. Accordingly, methods are provided for diagnosing microsatellite instability of a tumor, comprising determining the presence of these markers. Further, kits are provided to detect the presence of these markers (or subsets thereof) in a sample.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: May 21, 2019
    Assignees: Life Sciences Research Partners VZW, VIB VZW
    Inventor: Diether Lambrechts
  • Cytoplasmic protein complex comprising a kinase substrate sensor cells and associated detection methods
    Patent number: 10280410
    Abstract: The disclosure relates to a cytoplasmic protein complex comprising: (a) a first recombinant fusion protein comprising a kinase, fused to a first interaction polypeptide; and (b) a second recombinant fusion protein comprising a domain comprising a reporter phosphorylation site, whereby the domain is fused to a second interaction polypeptide. The disclosure relates further to a method to detect compound-compound-interaction using the cytoplasmic protein complex, and to cells comprising such cytoplasmic protein complex.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: May 7, 2019
    Assignees: UNIVERSITEIT GENT, VIB VZW
    Inventors: Jan Tavernier, Samuel Lievens
  • Opioid receptor binding agents and uses thereof
    Patent number: 10233241
    Abstract: Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 19, 2019
    Assignees: VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Jan Steyaert, Toon Laeremans, Els Pardon, Brian Kobilka, Aashish Manglik
  • Means and Methods for Regulating Secondary Metabolite Production in Plants
    Publication number: 20190071686
    Abstract: This disclosure relates to the field of secondary metabolite production in plants. More specifically, the disclosure relates to chimeric genes and their use in the regulation of biosynthesis and/or production of secondary metabolites in plants and plant-derived cell cultures.
    Type: Application
    Filed: August 21, 2018
    Publication date: March 7, 2019
    Applicants: VIB VZW, Universiteit Gent, Universiteit Leiden
    Inventors: Alain Goossens, Jan Mertens, Alex Van Moerkercke, Jacob Pollier, Johan Memelink
  • Cells producing Fc-containing molecules having altered glycosylation patterns and methods and use thereof
    Patent number: 10202590
    Abstract: The present application relates to the field of glyco-engineering, more specifically to glyco-engineering of Fc-containing molecules, such as antibodies. It is shown herein that Fc-containing molecules with a specific glycosylation pattern have a considerably longer circulating half-life in vivo, without having an altered binding affinity for their respective antigen. This has therapeutic implications in reducing the frequency with which these molecules need to be administered, without affecting therapeutic efficacy. Also, cells are provided that can produce the Fc molecules with the desired glycosylation pattern.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 12, 2019
    Assignees: VIB VZW, UNIVERSITEIT GENT
    Inventors: Nico L. M. Callewaert, Francis Santens
  • Brain Interaction Apparatus, Cranial Anchor, and Related Systems and Methods
    Publication number: 20180360367
    Abstract: A brain interaction apparatus is provided. The apparatus comprises a plurality of filaments; and a brain invasive launcher having a plurality of launching channels extending in a longitudinal direction between a proximal end and a distal end thereof. Each launching channel is configured for holding one of the plurality of filaments moveably arranged therein. At least one of the plurality of filaments is provided with a steering tip affixed to a distal end thereof. The steering tip comprises a portion tapering in a longitudinal direction of the at least one of the plurality of filaments thereby narrowing toward a distal end of the steering tip. The tapered portion is rotationally asymmetrical about a longitudinal axis of the at least one of the plurality of filaments.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 20, 2018
    Applicants: IMEC VZW, Katholieke Universiteit Leuven, KU LEUVEN R&D, VIB
    Inventors: Sebastian Haesler, Luis Diego Leon Hoffman
  • Liver-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 10149914
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: December 11, 2018
    Assignees: VIB VZW, Life Sciences Research Partners VZW, Universiteit Gent
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Respiratory syncytial virus vaccine
    Patent number: 10117926
    Abstract: Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: November 6, 2018
    Assignees: VIB VZW, UNIVERSITEIT GENT
    Inventors: Xavier Saelens, Bert Schepens, Walter Fiers
  • YEAST ALLELES INVOLVED IN TOLERANCE TO HIGH ALCOHOL LEVELS
    Publication number: 20180312878
    Abstract: The present application relates to the field of yeast and, specifically, to the identification of yeast alleles that are involved in maximal alcohol accumulation and/or in tolerance to high alcohol levels. The alcohol may be, e.g., ethanol. The identified alleles can be combined or stacked with each other to construe and/or select high alcohol tolerant yeasts, most notably Saccharomyces species.
    Type: Application
    Filed: September 2, 2016
    Publication date: November 1, 2018
    Applicants: VIB VZW, K.U. Leuven Research & Development
    Inventors: Kevin Verstrepen, Yudi Yang, Veerle Saels, Karin Voordeckers, Beatriz Herrera
  • Inhibition of PLGF to treat philadelphia chromosome positive leukemia
    Patent number: 10106601
    Abstract: The present application relates to the field of leukemias, and more in particular to how P1 GF inhibition can help to treat Philadelphia chromosome positive (Ph+) leukemias. Methods are provided for treating Ph+ leukemias by administering P1 GF inhibitors. Also disclosed are uses of P1 GF inhibitors in the treatment of Ph+ leukemias, or for the preparation of a medicament against Ph+ leukemias.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: October 23, 2018
    Assignees: VIB VZW, Life Sciences Research Partners VZW
    Inventors: Peter Carmeliet, Sonja Loges