Abstract: Metal chelates are useful for improving the contrast of X-ray, ultrasound, radionuclide and magnetic resonance (MR) images. However, the metal complexes must be stable and inert so that toxicity resulting from dissociation in the body can be minimized. This invention provides 16-member ring metal chelates that can provide a charge balanced metal complex having improved stability, especially for gadolinium(III) and samarium (III).
Type:
Application
Filed:
September 24, 2004
Publication date:
March 30, 2006
Applicants:
Hong Kong Polytechnic University, Victor Snieckus
Inventors:
Kwok-Yin Wong, Chi Huang, Cheuk-Sang Kwok, Victor Snieckus