Abstract: A membrane distillation arrangement (100) comprising: at least two dividers (120), each divider (120) having a top (122) and a base (124) and at least one side (126) which extends between the top (122) and the base (124); at least one transfer element (132) selected from a membrane, heat transfer component or combination thereof, each transfer element (132) having a top (134) and a base (136), each transfer element (132) being supported between two dividers (120); a plurality of perimeter seals (130), at least one perimeter seal (130) extending around the perimeter of the top (134) or the base (136) of each transfer element (132), each perimeter seal (130) forming a substantially fluid tight seal and a fluid flow space (140, 141) between the respective top (134) or base (136) of each transfer element (132) and a respective adjacent face of a divider (120).

Abstract: An antimicrobial packaging material for food stuffs containing from 0.05% to 1.5% by weight of a natural essential oil. The oil can be selected from primarily linalool and/or methylchavicol, but also from one or more of citral, geraniol, methyl cinnamate, methyl eugenol, 1,8-cineole, trans-a-bergamotene, carvacrol and thymol blended with one or more polymers selected from ethylene vinyl alcohol copolymer, polyacrylates, including ethyl acrylate methyl methacrylate copolymers, lonomers, nylons and other hydrophilic polymers or polymers possessing functional groups capable of partially anchoring the additives and the blender mix is coated onto the food contact face of a food grade packaging film or incorporated into a food grade packaging film. A binding agent such as polyethylene glycol is added to the blend to improve the retention of the volatile oil in the polymer during processing. This material has no regulatory limitations and, at the referred concentrations, does not form detectable off-flavors.

Abstract: Organic compounds, such as precursors for aryl ethylamines such as ephedrine, aryl propylamines such as fluoxetine and propionic acid derivatives such as ibuprofen, naproxen and fenoprofen, are subjected to a yeast mediated reduction conducted in the absence of a solvent. The yeast is moistened with water and contacted with the organic compound. The yeast may then be contacted with an organic solvent to dissolve the product of the reaction into the solvent, and a solid/liquid separation used to separate the product from the yeast.

Abstract: A method of object identification comprising, for an image in which an object is to be identified, determining for each of a set of location in the direction in which the gradient of intensity change to an adjacent location is greatest together with the magnitude of that gradient, modifying the gradient magnitude using a nonlinear function, the modified gradient and the associated direction for the set of location providing a vector representative of the image, and comparing the vector with a previously generated statistical model which provides identification of the object.

Abstract: A pipe inspection apparatus comprising an acoustic source (3) for location at a first position in a pipe or pipe network, one or more acoustic or pressure detectors (4) for location at one or more positions in the pipe or pipe network, means for recording and/or displaying a signal detected by the one or more detectors following the generation of an acoustic pulse, and means for allowing the comparison of the detected signal with a predetermined reference signal, differences between the detected and reference signals being indicative of a blockage or leakage in the pipe or pipe network (10).

Abstract: A method for the preparation of a compound of formula (VI): in which R2 is an optionally substituted C1–C6 alkyl; R4 is H, OH, an optionally substituted C1–C6 alkyl or an optionally substituted C1–C6 alkoxy; R5 is an optionally substituted aryl, an optionally substituted aralkyl, or an optionally substituted alkyl; and R6 is H or an optionally substituted C1–C6 alkyl; the method including the step of subjecting a ketone of formula (V) in which R2, R4 and R5 are as defined above, to reductive amination with an amine of formula R3NH2 in which R3 is an optionally substituted alkyl, and a reductant to form the compound of formula (VI), wherein the reaction is conducted in the presence of a supercritical fluid or a liquefied gas.

Abstract: An analysis for determining a characteristic cycle time of a sample. Active elements in the sample are excited with sufficient intensity and duration larger than the characteristic cycle time that at least some of the active elements are re-excited to an excited state substantially immediately following relaxation to a ground state, detecting quanta emitted by the active elements in the sample to obtain a detected signal, and analyzing the detected signal to derive the characteristic cycle time. The number of active elements in the sample and the intensity of the excitation are such that quanta are detected in a stream in which individual quanta are distinguishable from each other.

Abstract: A method of identifying an object class uses a model based upon appearance parameters derived by comparing images of objects of different classes. The model includes a representation of a probability density function describing a range over which appearance parameters may vary for a given class of object, the model further including a defined relationship between the appearance parameters and the probability density function. The method generates appearance parameters representative of an unknown object, estimates an appropriate probability density function for the unknown object using the defined relationship between the appearance parameters and the probability density function, then iteratively modifies at least some of the appearance parameters within limits determined using the probability density function to identify the object class.

Abstract: The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supereritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.

Abstract: Methods of treating a microbial infection comprising administering to a patient in need of such treatment are disclosed. In one aspect the method comprises administering to a patient in need of such treatment a therapeutically effective amount of Erythromycin B (or a pharmaceutically acceptable derivative thereof). In another aspect the method comprises a pharmaceutical composition comprising at least 50% by weight of Erythromycin B (or a pharmaceutically acceptable derivative thereof) of the total weight of antibiotic present in the composition. Also disclosed are 2?-esters of Erythromycin B and Erythromycin B enol ether.

Abstract: Organic compounds, such as precursors for aryl ethylamines such as ephedrine, aryl propylamines such as fluoxetine and propionic acid derivatives such as ibuprofen, naproxen and fenoprofen, are subjected to a yeast mediated reduction conducted in the absence of a solvent. The yeast is moistened with water and contacted with the organic compound. The yeast may then be contacted with an organic solvent to dissolve the product of the reaction into the solvent, and a solid/liquid separation used to separate the product from the yeast.

Abstract: A bioreductive conjugate comprises a bioreductive moiety with at least one therapeutic agent linked thereto and physiologically acceptable derivatives thereof. The bioreductive moiety incorporates an aromatic ring substituted with a nitro group and the conjugate is such that bioreduction of the nitro group causes release of the therapeutic agent by a through bond elimination and the residue of the bioreductive moiety to undergo an intramolecular cyclization reaction in which the nitrogen of the original nitro group provides an atom of the thus formed ring.

Abstract: A method of erasable/rewritable optical data storage is provided in which a laser beam from a laser (10) operated in either a pulsed or continuous wave mode is focussed by an optical system (11-18) onto a photorefractive polymeric material (32) to cause two photon excitation of the material to record data which may subsequently be erased by illuminating the material with radiation having a wavelength in the ultraviolet or visible spectrum to erase the recorded data. New photorefractive polymeric materials having a relatively narrow absorption band for use in the method are also disclosed.

Abstract: Electrical muscle stimulation relies upon the application to the muscles of a patient of a stimulating signal which comprises a series of regularly spaced bursts of pulses. Each burst includes a first component as a first continuous train of regularly spaced pulses and a second component as a series of regularly spaced second trains of regularly spaced pulses. The second component is combined with the first component and the spacing between successive pulses in the second pulse trains is less than the spacing between successive pulses in the first pulse train. A third component as a series of regularly spaced third trains of regularly spaced pulses may be combined with the first and second components, the spacing between successive pulses in the third pulse train being less than the spacing between successive pulses in the second pulse trains.

Abstract: A characteristic response of a medium to an excitation transient of predetermined duration which causes the medium to emit a series of signals over a period of time which is long relative to the duration of the excitation transient is assessed. The signals are detected and the duration of each interval between successive signals is measured. A relationship relating the interval between the excitation transient and the emission of each signal to the interval between each signal and the preceding signal in the series is derived to represent the characteristic response.

Abstract: A method for generating an intermediate representation of computer program code written for running on a programmable machine comprises: (i) generating a plurality of register objects for holding variable values to be generated by the program code; and (ii) generating a plurality of expression objects representing fixed values and/or relationships between said fixed values and said variable values according to said program code; said objects being organized into a branched tree-like network having all register objects at the lowest basic root or tree-trunk level of the network with no register object feeding into any other register object.

Abstract: A method for emulating a processor of a first endian type on a processor of a second endian type, wherein each memory access address B of string length L is transformed to the address A-B-L+S, wherein A is the total number of bytes allocated to a program, and S is the start address of the program.

Abstract: A method for generating an intermediate representation of computer program code written for running on a programmable machine comprises: (i) generating a plurality of register objects for holding variable values to be generated by the program code; and (ii) generating a plurality of expression objects representing fixed values and/or relationships between said fixed values and said variable values according to said program code; said objects being organized into a branched tree-like network having all register objects at the lowest basic root or tree-trunk level of the network with no register object feeding into any other register object.

Abstract: The present invention relates to yeast cells containing the SRB1/PSA1 gene and/or the PKC1 gene or functional derivatives thereof operatively linked to a heterologous inducible promoter and also to methods of regulating yeast cell lysis and flocculation and methods of fermentation using such yeast cells.

Abstract: A method of detecting an object located within a dynamic scattering media, includes i) directing a continuous coherent light wave of predetermined wavelength into the media; ii) detecting dynamically scattered light emerging from the media; iii) correlating the detected light photons in the time or frequency domain; iv) determining the presence of an object from analysis of differences between the correlation and a correlation which would arise from photons scattered by the media only; and v) determining the approximate position of the object within the media from the analysis of the correlation and knowledge of the mean transport path of the light wave of predetermined wavelength within the media.