Abstract: The present invention relates to novel piperazine derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially for targeted therapy treatment of hyperproliferative disorders, including benign hyperproliferative disorders, cancer and pre-cancer conditions.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.

Abstract: This invention relates to methods for preparation of jasmonate compounds via a salt of jasmonic acid.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for treating, inhibiting, or suppressing a hexokinase-2 (HK2)-expressing cancer.

Abstract: The present invention relates to novel piperazine derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially for targeted therapy treatment of hyperproliferative disorders, including benign hyperproliferative disorders, cancer and pre-cancer conditions.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for treating, inhibiting, or suppressing a hexokinase-2 (HK2)-expressing cancer.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.

Abstract: The present invention relates to novel piperazine derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially for targeted therapy treatment of hyperproliferative disorders, including benign hyperproliferative disorders, cancer and pre-cancer conditions.

Abstract: This invention relates to methods for preparation of jasmonate compounds via a salt of jasmonic acid.

Abstract: The present invention relates to novel pharmaceutical compositions for topical administration of a compound Formula I and methods of treating or preventing cancer or pre-cancerous conditions or benign hyperproliferative disorders, by administering the composition to a subject in need thereof. In particular, the present invention provides a stable formulation of active a compound of Formula I useful for the treatment of disorders such as actinic keratosis.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for treating, inhibiting, or suppressing a hexokinase-2 (HK2)-expressing cancer.

Abstract: The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine derivatives and pharmaceutical compositions including such compounds for inducing immune responses in a subject, including potentiating the immune response to hyperproliferative disorders such as cancer and potentiating the immune response to infectious diseases.

Abstract: A paper stock adapted to be employed in transport systems utilizing projecting pin-type sprocket drives includes at least one row of a plurality of spaced-apart and aligned pin-engageable drive apertures extending the length thereof, each of which drive apertures is formed by a partially open circular die-cut line having a gap between its ends of approximately 0.010 inches to 0.040 inches, the gap being oriented at the leading edge of the resulting aperture, thereby forming a strengthening hinge-like connection between the paper stock and the aperture blank when such blank is subsequently displaced, such as by engagement with a projecting pin on a drive sprocket mechanism of a transport system used to move paper stock through a machine.

Abstract: A precision hand-held label imprinter and dispenser includes a compact case or frame with a projecting handle and an applicator roller located remote therefrom, together with a dialable imprinter and platen assembly arranged so that a trigger lever associated with the handle may be manually acutated in one direction to imprint label stock (tape) by driving the platen across an imprinter in an engaged condition to force the printing medium and label stock thereagainst and operates in the opposite direction to separate the imprinter and platen and to simultaneously advance the printing medium and to advance the printed label stock to the applicator roller. Through a series of connected drive elements with the trigger lever, the device times the several functions so that accurate reproductions with high resolution of the dialed imprint information on each label is assured.