Abstract: Aspects of the application provide anti-hemojuvelin antibodies and methods of using the same in treating anemias of chronic disease, iron-restricted anemias, and/or conditions associated with anemia.

Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Abstract: The present invention relates spiro-cyclic amine derivatives of the formula (1) wherein R1; R2; R3; Q; —W-T-; R5; Z; and A have the definitions provided in the claims; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more N-oxides thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of diseases and conditions in which (a) S1P receptor (s) is (are) involved.

Abstract: A method and apparatus enabling the distribution of hyper-relevant advertising to consumers who have confirmed interests in specific content, products, and services is described. Users define “who they are” and “what they want” in a spontaneous, guided, voluntary disclosure of rich, candid, personal information conceived to attract individuals who seek or share common relationships, experiences, objectives, skills, knowledge, acquaintances, interests, needs, or desires for mutual gain. The information is converted into encrypted user codes; these codes are used to generate precisely controlled electronic encounters, the creation and delivery of highly personalized hyper-relevant advertising, and the gathering of amounts of research data through the ad hoc interaction of unique mobile devices.