Abstract: The disclosure provides Fc?RIIA-binding molecules, for example, humanized monoclonal antibodies capable of inhibiting Fc?RIIA activity, and methods of using the Fc?RIIA binding molecules, for example, in treating or preventing inflammatory, immune-mediated, or autoimmune diseases or disorders.
Type:
Grant
Filed:
March 1, 2022
Date of Patent:
September 5, 2023
Assignee:
Viela Bio, Inc.
Inventors:
Katherine Ann Vousden, Bo Chen, Gary Patrick Sims
Abstract: The present invention is directed to ILT7 binding molecules, e.g., anti-ILT7 antibodies, and methods for treating or preventing conditions and diseases associated with ILT7-expressing cells such as autoimmune diseases.
Type:
Grant
Filed:
June 17, 2021
Date of Patent:
June 13, 2023
Assignee:
Viela Bio, Inc.
Inventors:
Katherine Ann Vousden, Julie Ann Douthwaite, Melissa Marie Damschroder, Miguel Angel Sanjuan
Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
Type:
Grant
Filed:
July 28, 2021
Date of Patent:
January 17, 2023
Assignee:
Viela Bio, Inc.
Inventors:
Anthony Coyle, Manuel Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer
Abstract: The disclosure provides Fc?RIIA-binding molecules, for example, humanized monoclonal antibodies capable of inhibiting Fc?RIIA activity, and methods of using the Fc?RIIA binding molecules, for example, in treating or preventing inflammatory, immune-mediated, or autoimmune diseases or disorders.
Type:
Application
Filed:
March 1, 2022
Publication date:
December 1, 2022
Applicant:
VIELA BIO, INC.
Inventors:
Katherine Ann Vousden, Bo Chen, Gary Patrick Sims
Abstract: The disclosure provides Fc?RIIA-binding molecules, for example, humanized monoclonal antibodies capable of inhibiting Fc?RIIA activity, and methods of using the Fc?RIIA binding molecules, for example, in treating or preventing inflammatory, immune-mediated, or autoimmune diseases or disorders.
Type:
Grant
Filed:
April 28, 2017
Date of Patent:
April 19, 2022
Assignee:
Viela Bio, Inc.
Inventors:
Katherine Ann Vousden, Bo Chen, Gary Patrick Sims
Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
Type:
Application
Filed:
July 28, 2021
Publication date:
March 24, 2022
Applicant:
Viela Bio, Inc.
Inventors:
Anthony COYLE, Manuel BACA, Thomas THISTED, Stacey DRABIC, Luba GRINBERG, Shabazz NOVARRA, Vaheh OGANESYAN, Ronald HERBST, David SPENCER
Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
Type:
Grant
Filed:
May 31, 2018
Date of Patent:
August 31, 2021
Assignee:
VIELA BIO, INC.
Inventors:
Anthony Coyle, Manual Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer
Abstract: The present invention is directed to ILT7 binding molecules, e.g., anti-ILT7 antibodies, and methods for treating or preventing conditions and diseases associated with ILT7-expressing cells such as autoimmune diseases.
Type:
Grant
Filed:
March 9, 2017
Date of Patent:
July 27, 2021
Assignee:
Viela Bio, Inc.
Inventors:
Katherine Ann Vousden, Julie Ann Douthwaite, Melissa Marie Damschroder, Miguel Angel Sanjuan
Abstract: The present invention is directed to ILT7 binding molecules, e.g., anti-ILT7 antibodies, and methods for treating or preventing conditions and diseases associated with ILT7-expressing cells such as autoimmune diseases.
Type:
Application
Filed:
March 9, 2017
Publication date:
October 29, 2020
Applicant:
Viela Bio, Inc
Inventors:
Katherine Ann VOUSDEN, Julie Ann DOUTHWAITE, Melissa Marie DAMSCHRODER, Miguel Angel SANJUAN
Abstract: The disclosure provides Fc?RIIA-binding molecules, for example, humanized monoclonal antibodies capable of inhibiting Fc?RIIA activity, and methods of using the Fc?RIIA binding molecules, for example, in treating or preventing inflammatory, immune-mediated, or autoimmune diseases or disorders.
Type:
Application
Filed:
April 28, 2017
Publication date:
January 2, 2020
Applicant:
Viela Bio, Inc.
Inventors:
Katherine Ann Vousden, Bo Chen, Gary Patrick Sims
Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
Type:
Grant
Filed:
October 10, 2012
Date of Patent:
June 19, 2018
Assignee:
Viela Bio, Inc.
Inventors:
Anthony Coyle, Manuel Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer