Abstract: A radiation therapy system comprises a magnetic resonance imaging (MRI) system combined with an irradiation system, which can include one or more linear accelerators (linacs) that can emit respective radiation beams suitable for radiation therapy. The MRI system includes a split magnet system, comprising first and second main magnets separated by gap. A gantry is positioned in the gap between the main MRI magnets and supports the linac(s) of the irradiation system. The gantry is rotatable independently of the MM system and can angularly reposition the linac(s). Shielding can also be provided in the form of magnetic and/or RF shielding. Magnetic shielding can be provided for shielding the linac(s) from the magnetic field generated by the MM magnets. RF shielding can be provided for shielding the MRI system from RF radiation from the linac.

Abstract: Magnetic resonance (MR) guided radiation therapy (MRgRT) enables control over the delivery of radiation based on patient motion indicated by MR imaging (MRI) images captured during radiation delivery. A method for MRgRT includes: simultaneously using one or more radiation therapy heads to deliver radiation and an MRI system to perform MRI; using a processor to determine whether one or more gates are triggered based on at least a portion of MRI images captured during the delivery of radiation; and in response to determining that one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation, suspending the delivery of radiation.

Abstract: A photon therapy delivery system can deliver radiation therapy to a patient via a photon beam. The system can utilize a controller configured to facilitate delivery of radiation therapy via a photon beam and also a particle beam. This can include receiving radiation therapy beam information for radiation therapy treatment of a patient utilizing the particle beam and photon beam. Also, patient magnetic resonance imaging (MRI) data can be received during the radiation therapy treatment. Utilizing the patient MRI data, real-time calculations of a location of dose deposition for the particle beam and for the photon beam can be determined taking into account interaction properties of soft tissues through which the particle beam passes.

Abstract: A surgical guidance system is disclosed that allows for real-time imaging and patient monitoring during a surgical procedure. The system can include an MRI system for generating real-time images of the patient while surgery is being performed. Prior to surgery, a surgical plan can be created using a planning interface. A control unit receives the real-time image data and the surgical plan, and monitors the image data based on parameters included in the surgical plan. The control-unit monitoring occurs in real-time while the surgical procedure is being performed. The control unit can detect deviations from the surgical plan and/or high-risk patient conditions and instruct an alert unit to issue an alert based on the detected conditions.

Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.

Abstract: Edema in tissue of a patient undergoing a course of radiation therapy or treatment can be estimated based on one or more MRI measurements used to measure changes in fluid content of various tissues. A correlation between observed changes in edema and one or more delivered fractions of radiation can be used to drive one or more clinical actions. Methods, systems, articles of manufacture, and the like are described.

Abstract: Edema in tissue of a patient undergoing a course of radiation therapy or treatment can be estimated based on one or more MRI measurements used to measure changes in fluid content of various tissues. A correlation between observed changes in edema and one or more delivered fractions of radiation can be used to drive one or more clinical actions. Methods, systems, articles of manufacture, and the like are described.

Abstract: An ion chamber has a chamber having an interior volume. There is a first electrode and a second electrode in the chamber and separated by a gap. A collector electrode is positioned between the first electrode and the second electrode. The collector electrode is shaped to occlude a portion of the first electrode from the second electrode.

Abstract: Systems and methods for tomographic reconstruction of an image include systems and methods for producing images from k-space data. A k-space data set of an imaged object is acquired using know k-space data acquisition systems and methods. A portion of the k-space data set is sampled so as to collect some portion of the k-space data. An image is then reconstructed from the collected portion of the k-space data set according to a convex optimization model.

Abstract: Gradient coil assemblies for horizontal magnetic resonance imaging systems (MRIs) and methods of their manufacture. Some embodiments may be used with open MRIs and can be used with an instrument placed in the gap of the MRI. In general, concentrations of conductors or radially oriented conductors may be moved away from the gap of the MRI so as to reduce eddy currents that may be induced in any instrument placed within the gap. Systems for directly cooling primary gradient and shield coils may be utilized and various coil supporting structures may be used to assist in coil alignment or to facilitate use of an instrument in the MRI gap.

Abstract: Apparatuses, methods, and computer program products for reducing an appearance of an artifact in an image generated by a magnetic resonance imaging (MRI) system are disclosed. The apparatus includes a magnetic field generating device configured to create an inhomogeneity in the magnetic field of an MRI system and prevent at least one out-of-field excitation during imaging.

Abstract: Systems and methods for tomographic reconstruction of an image include systems and methods for producing images from k-space data. A k-space data set of an imaged object is acquired using know k-space data acquisition systems and methods. A portion of the k-space data set is sampled so as to collect some portion of the k-space data. An image is then reconstructed from the collected portion of the k-space data set according to a convex optimization model.

Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.

Abstract: A system has a linear accelerator, ion pump and a compensating magnet. The ion pump includes an ion pump magnet position, an ion pump magnet shape, an ion pump magnet orientation, and an ion pump magnet magnetic field profile. The compensating magnet has a position, a shape, an orientation, and a magnetic field profile, where at least one of the position, shape, orientation, and magnetic field profile of the compensating magnet reduce at least one component of a magnetic field in the linear accelerator resulting from the ion pump magnet.

Abstract: A system including a diagnostic-quality CT scanner for imaging a patient, the diagnostic-quality CT scanner having an imaging isocenter and a radiation therapy device positioned adjacent the diagnostic-quality CT scanner, the radiation therapy device including a gantry carrying a radiation therapy beam source and having a radiation therapy isocenter separate from the imaging isocenter of the diagnostic-quality CT scanner. The system including a couch configured to position the patient for imaging and for radiation therapy by translating the patient between the diagnostic quality CT scanner and the radiation therapy device.

Abstract: Edema in tissue of a patient undergoing a course of radiation therapy or treatment can be estimated based on one or more MRI measurements used to measure changes in fluid content of various tissues. A correlation between observed changes in edema and one or more delivered fractions of radiation can be used to drive one or more clinical actions. Methods, systems, articles of manufacture, and the like are described.

Abstract: A collimating system for collimating a radiation beam having a first multileaf collimator and a second multileaf collimator configured such that the radiation beam will pass through the first multileaf collimator before passing through the second multileaf collimator, and pass through the second multileaf collimator before hitting its target. The leaves of the first multileaf collimator and the leaves of the second multileaf collimator may be configured to move independently of one another.

Abstract: Edema in tissue of a patient undergoing a course of radiation therapy or treatment can be estimated based on one or more MRI measurements used to measure changes in fluid content of various tissues. A correlation between observed changes in edema and one or more delivered fractions of radiation can be used to drive one or more clinical actions. Methods, systems, articles of manufacture, and the like are described.

Abstract: Systems and methods for delivery of radiotherapy in conjunction with magnetic resonance imaging in which various conductors, shields and shims may be used to solve issues occurring when radiation therapy equipment is placed in the vicinity of an magnetic resonance imaging system.

Abstract: Active resistive shim coil assemblies may be used in magnetic resonance imaging (MRI) systems to reduce in-homogeneity of the magnetic field in the imaging volume. Disclosed embodiments may be used with continuous systems, gapped cylindrical systems, or vertically gapped systems. Disclosed embodiments may also be used with an open MRI system and can be used with an instrument placed in the gap of the MRI system. An exemplary embodiment of the active resistive shim coil assembly of the present disclosure includes active resistive shim coils each operable to be energized by separate currents through a plurality of power channels. In some embodiments, the disclosed active resistive shim coil assemblies allow for various degrees of freedom to shim out field in-homogeneity.