Abstract: A glove box with a leakage shielding space (4) comprises a main box body, a view window (8) placed on the main box body, glove ports installed on the view window (8), side panels attached to the main box body, and an antechamber (1) installed on a side panel. Wherein, on at least one of five interfaces, namely, between the main box body and the view window (8), between the main box body and the side panel, between the view window (8) and the glove port, between the glove port and the glove, between the side panel and the antechamber (1), a leakage shielding space (4) is formed, so as to ensure the purity in the operating space of the glove box and to prevent the external environment of the box body from being polluted.